Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus.
Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus.
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DOI：
10.1080/20022727.2017.1341758
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Morishita Y
中科院分区：
文献类型：
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作者：
Ito K;Ookawara S;Ishibashi K;Morishita Y
利用纳米载体（如病毒和非病毒载体）靶向胰腺和肠道的基因治疗可以改善对血糖水平的控制，从而改善糖尿病患者的预后。同种异体胰岛细胞移植使用这种递送系统已经发展成为治疗糖尿病的选择。本文综述了转基因和利用纳米载体的胰岛细胞传递系统在糖尿病治疗中的应用。
Gene therapy that targets the pancreas and intestines with delivery systems using nano-sized carriers such as viral and non-viral vectors could improve the control of blood glucose levels, resulting in an improved prognosis for patients with diabetes mellitus. Allogenic pancreatic islet cell transplantations using such delivery systems have been developed as therapeutic options for diabetes mellitus. This review focuses on transgenes and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus.