Investigation of BRAF mutation in a series of papillary thyroid carcinoma and matched-lymph node metastasis reveals a new mutation in metastasis
Investigation of BRAF mutation in a series of papillary thyroid carcinoma and matched-lymph node metastasis reveals a new mutation in metastasis
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DOI：
10.1111/j.1365-2265.2005.02235.x
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发表时间：
2005-04-01
影响因子：
3.2
通讯作者：
Cerutti, J
中科院分区：
文献类型：
--
作者：
Oler, G;Ebina, KN;Cerutti, J
据报道，BRAF基因的激活点突变被确定为甲状腺乳头状癌（PTC）中最常见的遗传事件。BRAF 1799T？肿瘤的转移、晚期及侵袭性行为；BRAF 1799T的患病率？一系列配对PTC原发肿瘤和淋巴结转移的突变；PTC经典变异及其5个卵泡变异的特征分析。
Reports that an activated point mutation in the BRAF gene was identified as the most common genetic event in papillary thyroid carcinoma (PTC). Correlation between the BRAF 1799T? A transversion and advanced clinical stage and aggressive tumor behavior; Prevalence of the BRAF 1799T? A mutation in a series of paired PTC primary tumor and lymph node metastases; Characterization of the classic variants of PTC and its five follicular variants.