Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice
Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice
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DOI：
10.1099/vir.0.024117-0
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发表时间：
2010-11-01
影响因子：
3.8
通讯作者：
Ortego, Javier
中科院分区：
文献类型：
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作者：
Calvo-Pinilla, Eva;Maria Nieto, Jose;Ortego, Javier
确定蓝舌病病毒（BTV）的传播途径对改善疾病控制至关重要。虽然BTV主要通过几种库蠓传播，但有证据表明其通过胎盘和口腔传播。我们现在报告IFNAR（（-/-））小鼠对BTV-8的口腔感染易感。病毒血症、临床表现和组织病变与静脉感染小鼠相似。此外，我们发现，口腔和食管是易感的BTV感染和复制，这表明这些器官是BTV口腔感染的可能进入途径。
The identification of transmission routes for bluetongue virus (BTV) is essential to improve the control of the disease. Although BTV is primarily transmitted by several species of Culicoides biting midges, there has been evidence of transplacental and oral transmission. We now report that IFNAR((-/-)) mice are susceptible to oral infection by BTV-8. Viraemia, clinical manifestations and tissue lesions are similar to those in intravenously infected mice. In addition, we show that the oral cavity and oesophagus are susceptible to BTV infection and replication, suggesting that these organs are possible entry routes during BTV oral infection.