Occurrence, spatiotemporal variation, and ecological risk of antibiotics in the water of the semi-enclosed urbanized Jiaozhou Bay in eastern China
Occurrence, spatiotemporal variation, and ecological risk of antibiotics in the water of the semi-enclosed urbanized Jiaozhou Bay in eastern China
复制标题
中国东部半封闭城市化胶州湾水域抗生素的存在、时空变化及生态风险
DOI：
10.1016/j.watres.2020.116187
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发表时间：
2020-10-01
期刊：
影响因子：
12.8
通讯作者：
He, Mengchang
中科院分区：
文献类型：
--
作者：
Lu, Shuang;Lin, Chunye;He, Mengchang
抗生素在世界各地沿海海湾和河口的发生、时间变化和空间变化没有很好的文献记录或了解。对半封闭式都市化海湾中国胶州湾水域中的15种目标抗生素进行了夏季和冬季监测。检测到14种抗生素(不包括泰乐菌素)，表明其残留在海湾广泛存在。抗菌素总浓度河口水为71.8ngL-1~840ngL-1，显著高于湾水(38.7ngL-1)。湾水中的抗生素种类以氟喹诺酮类和β-内酰胺类为主，占抗生素总浓度的近90%。此外，在检测到的14种抗生素中，阿莫西林污染最突出，占抗生素总浓度的44%。海湾水中阿莫西林、白霉素、恩诺沙星和磺胺间甲氧西林的浓度通常高于世界各地沿海海湾和河口的报告浓度。湾水中抗生素总浓度夏季平均值为84.7ngL-1，明显低于冬季的129.0 ngL-1。这主要是由于夏季径流的高度稀释所致。海湾水中氟苯尼考的浓度夏季显着高于冬季，这是由于其在夏季水产养殖中的使用量较高。在空间上，抗生素总浓度(夏季和冬季)在海湾东海岸的水中较高，那里的人口和医院密度都很高。然而，夏季海湾东北部水产养殖区兽用抗生素浓度总和较高。风险评估显示，阿莫西林和恩诺沙星可能对海湾中的藻类构成高风险(风险商数为1)。在今后的研究中，应考虑药物混合物的协同效应和抗生素通过食物网的生物积累。(C)2020爱思唯尔有限公司。保留所有权利。
The occurrence, temporal variation, and spatial variation of antibiotics in coastal bays and estuaries worldwide are not well documented or understood. Fifteen target antibiotics within the five classes of beta-lactams, amphenicols, macrolides, fluoroquinolones, and sulfonamides were measured during the summer and winter in the water of Jiaozhou Bay in China, which is a semi-enclosed urbanized bay. Fourteen antibiotics (excluding tylosin) were detected, thus demonstrating the widespread occurrence of their residues in the bay. The total antibiotic concentration ranged from 71.8 ng L-1 to 840 ng L-1 for the estuarine water, which was significantly higher than that for the bay water (38.7-181 ng L-1). The antibiotic classes in the bay water were dominated by fluoroquinolones and beta-lactams, which accounted for nearly 90% of the total antibiotic concentration. In addition, amoxicillin contamination was the most prominent among the 14 detected antibiotics as it accounted for similar to 44% of the total antibiotic concentration. The concentrations of amoxicillin, leucomycin, enrofloxacin, and sulfamonomethoxine in the bay water were usually higher than those reported for coastal bays and estuaries worldwide. The average total antibiotic concentration in the bay water was 84.7 ng L-1 during the summer, which was significantly lower than that during the winter (129.0 ng L-1). This was mainly due to high dilution by runoffduring the summer. The florfenicol concentration in the bay water was significantly higher during the summer than in winter due to its higher usage in aquaculture during the summer. Spatially, the total antibiotic concentration (both summer and winter) was higher in the water along the eastern coast of the bay, where the population and hospital densities are high. However, the sum of the veterinary antibiotic concentrations was higher in the northeastern aquaculture area of the bay during the summer. A risk assessment revealed that amoxicillin and enrofloxacin could pose high risks (risk quotient of > 1) to algae in the bay. The synergic effects of pharmaceutical mixtures and the bioaccumulation of antibiotics through the food web should be considered in future studies. (C) 2020 Elsevier Ltd. All rights reserved.