Chronic severe axonal polyneuropathy associated with hyperthyroidism and multivitamin deficiency.
Chronic severe axonal polyneuropathy associated with hyperthyroidism and multivitamin deficiency.
复制标题
与甲状腺功能亢进和多种维生素缺乏相关的慢性严重轴突多发性神经病。
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. Ueno
中科院分区：
文献类型：
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作者：
K. Sugie;F. Umehara;H. Kataoka;A. Kumazawa;S. Ueno
目标
甲状腺功能亢进症常伴有各种神经肌肉疾病，最常见的是近端肌病。甲状腺机能亢进症的周围神经受累是非常罕见的，很少有报道。我们描述了一个29岁的女性未经治疗的甲状腺功能亢进症谁提出了慢性严重轴突感觉运动多发性神经病。周围神经受累与甲亢的其他症状一起发展2年前介绍。过去6个月，她还患有神经性厌食症，导致多种维生素缺乏症。
结果
电生理、病理检查及临床表现证实为严重轴索性多发性神经病。神经性厌食症被认为是未经治疗的甲状腺功能亢进症的一种表现。我们认为甲状腺机能亢进症是我们病人多发性神经病的一个重要原因，虽然甲状腺机能亢进症的周围神经受累是罕见的。据我们所知，这是第一个记录的情况下，慢性严重轴索多发性神经病归因于甲状腺功能亢进症和多种维生素缺乏症。
结论
我们的研究结果有力地表明，不仅多种维生素缺乏症，而且甲状腺功能亢进症可以引起轴突多发性神经病，从而扩大了甲状腺功能亢进症的临床谱。
OBJECTIVES
Hyperthyroidism is often associated with various neuromuscular disorders, most commonly proximal myopathy. Peripheral nerve involvement in hyperthyroidism is very uncommon and has rarely been reported. We describe a 29-year-old woman with untreated hyperthyroidism who presented with chronic severe axonal sensory-motor polyneuropathy. Peripheral nerve involvement developed together with other symptoms of hyperthyroidism 2 years before presentation. She also had anorexia nervosa for the past 6 months, resulting in multivitamin deficiency.
RESULTS
Electrophysiological and pathological findings as well as clinical manifestations confirmed the diagnosis of severe axonal polyneuropathy. Anorexia nervosa has been considered a manifestation of untreated hyperthyroidism. We considered hyperthyroidism to be an important causal factor in the polyneuropathy in our patient, although peripheral nerve involvement in hyperthyroidism is rare. To our knowledge, this is the first documented case of chronic severe axonal polyneuropathy ascribed to both hyperthyroidism and multivitamin deficiency.
CONCLUSION
Our findings strongly suggest that not only multivitamin deficiency, but also hyperthyroidism can cause axonal polyneuropathy, thus expanding the clinical spectrum of hyperthyroidism.
影响因子：
44.1
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通讯作者：
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