Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: Clinical outcome and length of hospitalization
Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: Clinical outcome and length of hospitalization
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DOI：
10.1086/340616
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发表时间：
2002-06-15
影响因子：
11.8
通讯作者：
Colardyn, F
中科院分区：
文献类型：
--
作者：
Blot, S;Vandewoude, K;Colardyn, F
回顾性比较由抗生素敏感（AB-S, n = 208）或耐药（AB-R, n = 120）革兰氏阴性菌引起的院内菌血症危重患者的人群特征和结局。两组之间在疾病严重程度和合并症因素方面无显著差异。由AB-R菌株引起的菌血症患者在菌血症发作前住院时间较长。AB-S菌血症患者住院死亡率为41.8%；感染AB-R株的患者为45.0% （P = 0.576）。一项多变量生存分析表明，年龄较大（P = 0.009）、菌血症高危来源（腹部和下呼吸道；P = 0.031）以及急性生理和慢性健康评估ii相关的高预期死亡率（P = 0.032）与住院死亡率独立相关（P = 0.032）
Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n = 208) or antibiotic-resistant (AB-R; n = 120) gram-negative bacteria. No significant differences in severity of illness and comorbidity factors were seen between groups. Patients with bacteremia caused by AB-R strains had a longer hospitalization before the onset of the bacteremia. The in-hospital mortality for patients with bacteremia caused by AB-S strains was 41.8%; for patients infected with AB-R strains, it was 45.0% (P = .576). A multivariate survival analysis demonstrated that older age (P = .009), a high-risk source of bacteremia (abdominal and lower respiratory tract; P = .031), and a high acute physiology and chronic health evaluation II-related expected mortality (P = .032) were independently associated with in-hospital mortality (P