Functional hepatic volume measured by technetium-99m-galactosyl-human serum albumin liver scintigraphy: comparison between hepatocyte volume and liver volume by computed tomography
Functional hepatic volume measured by technetium-99m-galactosyl-human serum albumin liver scintigraphy: comparison between hepatocyte volume and liver volume by computed tomography
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锝-99m-半乳糖基-人血清白蛋白肝脏闪烁扫描仪测量功能性肝体积：肝细胞体积与计算机断层扫描肝脏体积的比较
DOI：
10.1111/j.1572-0241.2001.03556.x
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发表时间：
2001
影响因子：
9.8
通讯作者：
Y. Kamiyama
中科院分区：
文献类型：
--
作者：
Hon A Kwon;Y. Matsui;S. Ha‐Kawa;Y. Kamiyama
目的：探讨99m-锝半乳糖-人血清白蛋白显像（GSA-LV）单光子发射CT测量肝脏功能体积的有效性。然后，我们将该值与肝胆肿瘤患者的总肝细胞体积和CT （CT- lv）测定的肝体积进行比较。方法：47例患者分为两组，SM组（亚节段切除术和单节段切除术）和DT组（分离节段切除术和三节段切除术）。这些组进一步分为有或无慢性肝炎或肝硬化的亚组。计算GSA-LV、CT-LV及肝细胞总体积。术前、术后2周和4周以及术后3月和6月分别进行GSA-LV和CT-LV测量。结果：术前GSA-LV值与肝细胞体积、吲哚菁绿15min保留率（ICGR15）显著相关。同样，肝细胞体积与CT-LV和ICGR15有很好的相关性。然而，CT-LV仅与ICGR15相关。DT组GSA-LV恢复延迟，约90%的体积和功能再生是在肝切除术后6个月内观察到的。相比之下，DT组正常肝残体患者的CT-LV在肝切除术后1个月内恢复到约90%的初始体积，而损伤肝患者的CT-LV在肝切除术后6个月逐渐再生并恢复到约80%的术前体积。结论：我们的结论是，使用GSA-LV测量功能肝容量有助于基于肝细胞体积全面评估肝功能。
OBJECTIVES:We investigated the usefulness of measuring the functional hepatic volume by single-photon emission CT with 99m-technetium galactosyl-human serum albumin scintigraphy (GSA-LV). We then compared this value to the total hepatocyte volume and the hepatic volume determined from CT (CT-LV) in the patients with hepatobiliary tumors.METHODS:Forty-seven patients were divided into two groups, the SM group (subsegmentectomy and monosegmentectomy) and the DT group (disegmentectomy and trisegmentectomy). These groups were further divided into subgroups with or without chronic hepatitis or cirrhosis. The GSA-LV, CT-LV, and the total hepatocyte volume were then calculated. The GSA-LV and CT-LV measurements were performed preoperatively, at 2 and 4 wk, and at 3 and 6 months after surgery.RESULTS:The preoperative GSA-LV values were significantly correlated with the hepatocyte volume and the 15-min retention rate of indocyanine green (ICGR15). Similarly, the hepatocyte volume correlated well with the CT-LV and ICGR15. However, the CT-LV was correlated only with the ICGR15. Recovery of the GSA-LV in the DT group was delayed, and about 90% of the volumetric and functional regeneration was observed within 6 months after the hepatectomy. In contrast, the CT-LV of DT group patients with normal liver remnants returned to approximately 90% of their initial volume within 1 month after the hepatectomy, whereas patients with injured livers regenerated gradually and regained approximately 80% of their preoperative value by 6 months after the hepatectomy.CONCLUSIONS:We conclude that the measurement of functional hepatic volume using the GSA-LV is useful in fully evaluating hepatic function based on hepatocyte volume.