Tumors of Fibrous Tissue
Tumors of Fibrous Tissue
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纤维组织肿瘤
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
J. Vandevenne
中科院分区：
文献类型：
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作者：
A. Schepper;J. Vandevenne
纤维组织由成纤维细胞和细胞外基质组成，细胞外基质含有细胞结构（胶原蛋白、弹性蛋白）和非细胞性凝胶样基质。成纤维细胞（梭形细胞）和肌成纤维细胞（它们是显示成纤维细胞和平滑肌细胞共有特征的修饰成纤维细胞）都产生前胶原和胶原蛋白。胶原蛋白是细胞外基质的主要成分，形成功能和分布不同的密切相关的非收缩性结构的异质组。弹性蛋白是与胶原纤维密切相关的弹性纤维的主要成分。结缔组织的基质是糖胺聚糖（粘多糖），最常见的类型是透明质酸和4-硫酸软骨素和6-硫酸软骨素。弹性蛋白和糖胺聚糖也由成纤维细胞合成[17，48]。
Fibrous tissue consists of fibroblasts and an extracellular matrix containing both fibrillary structures (collagen, elastin) and nonfibrillary, gel-like ground substance. Both fibroblasts (spindle-shaped cells) and myofibroblasts, which are modified fibroblasts showing features common to fibroblasts and smooth muscle cells, produce procollagen and collagen Collagen is the main component of the extracellular matrix, forming a heterogeneous group of closely related, noncontractile structures varying in function and distribution. Elastin is the main component of elastic fibers that are closely associated with collagen fibers. The ground substance of connective tissue is glycosaminoglycans (mucopolysaccharides), the most common types being hyaluronic acid and chondroitin 4- and 6-sulfates. Both elastin and glycosaminoglycans are also synthesized by fibroblasts [17, 48].