Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity.
Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity.
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T 细胞受体的高亲和力和低亲和力抗体都可以具有激动剂或拮抗剂活性。
DOI：
10.1016/1074-7613(94)90046-9
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发表时间：
1994
期刊：
影响因子：
32.4
通讯作者：
JanewayJr,CA
中科院分区：
文献类型：
--
作者：
Yoon,ST;Dianzani,U;Bottomly,K;JanewayJr,CA
抗TCR抗体可以激活或阻断T细胞的激活。在本实验中，我们已经表明，针对相同TCR的不同单克隆抗体可以具有激动剂或拮抗剂活性，并且我们已经检查了这些功能效应与抗体对TCR的亲合力之间的关系。我们在这里表明，它不是一个抗TCR抗体的亲合力，决定它是否作为一个激动剂或拮抗剂。此外，我们表明，单价Fab片段的激动剂抗体产生可检测的变化，T细胞的行为。这些数据表明，T细胞活化可能不仅涉及TCR的聚集，而且还涉及个别连接受体的一些诱导变化，并且激动剂可能产生这种变化，而拮抗剂则不会。我们认为，类似的效果可能也适用于肽-MHC配体。
Anti-TCR antibodies can activate or block the activation of T cells. In the present experiments, we have shown that different monoclonal antibodies to the same TCR can have either agonist or antagonist activity, and we have examined the relationship between these functional effects and the avidity of the antibody for the TCR. We show here that it is not the avidity of an anti-TCR antibody that determines whether it acts as an agonist or an antagonist. Moreover, we show that monovalent Fab fragments of agonist antibodies produce detectable changes in T cell behavior. These data suggest that T cell activation may involve not just aggregation of the TCR but also some induced change in individual ligated receptors, and that agonists may produce this change while antagonists do not. We argue that similar effects may apply to peptide-MHC ligands as well.