Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism.
Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism.
复制标题
Neothalfine，一种针对转移性结直肠癌的有效天然抗肿瘤剂及其主要机制。
DOI：
10.1016/j.bmc.2020.115849
复制
发表时间：
2020-11
影响因子：
3.5
通讯作者：
Luo Xiao-Dong
中科院分区：
文献类型：
--
作者：
Zhu Yan-Yan;Jin Qiong;Chen Shan-Shan;Jin Dan-Ni;Wang Zhao-Jie;He Ying-Jie;Chen Hui-Cheng;Zhao Yun-Li;Zhao Li-Xing;Dai Zhi;Luo Xiao-Dong
Neothalfine is a natural bisbenzylisoquinoline alkaloid with the abundant resource in medicinal plants and has not been reported its anti-tumor efficacy. In the present study, the anti-tumor efficacy was investigated and it showed broad-spectrum activity against several cancer cell lines, especially metastatic colorectal cancer (HCT116, SW620, T84) with the IC50values of 7.2, 5.9, 8.2 nM, respectively, roughly equal to well-known anti-tumor agent docetaxel (4.0, 4.7, 2.7 nM) and nearly 1000 folds than CPT-11 (4.4, 5.1, 6.9 μM). Furthermore, neothalfine inhibited colorectal cell proliferation by resulting in cell cycle arrest at the G2/M phase and induced apoptosis through the dysfunction of mitochondria to trigger intrinsic apoptotic pathway by untargeted metabolomic method, mitochondrial membrane potential, and caspase-3/7 activity assay. Moreover, neothalfine damaged colorectal cancer clonal spheres expansion significantly at the concentration of 3.5 nM with nearly 1000 folds efficacy than CPT-11 (3.0 µM). The results supported that neothalfine might be an anti-tumor lead for further investigation.
登录
查看更多内容
影响因子：
1.5
作者：
M. Mihăşan
通讯作者：
M. Mihăşan
DOI：
10.1007/s11626-019-00332-9
发表时间：
2019-05-01
影响因子：
2.1
作者：
Bhagya, N.;Chandrashekar, K. R.;Rekha, P. D.
通讯作者：
Rekha, P. D.
影响因子：
4.3
作者：
Panczyk, Mariusz
通讯作者：
Panczyk, Mariusz
α-酮戊二酸通过抑制 mTOR 和激活 AMPK 延长果蝇寿命
影响因子：
5.2
作者：
Su, Yuan;Wang, Tao;Yang, Mingyao
通讯作者：
Yang, Mingyao
影响因子：
5.7
作者：
Kong, Li Ren;Chua, Kian Ngiap;Goh, Boon Cher
通讯作者：
Goh, Boon Cher