To Be Sure, To Be Sure: Intolerance of Uncertainty Mediates Symptoms of Various Anxiety Disorders and Depression
To Be Sure, To Be Sure: Intolerance of Uncertainty Mediates Symptoms of Various Anxiety Disorders and Depression
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DOI：
10.1016/j.beth.2011.02.007
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发表时间：
2012-09-01
期刊：
影响因子：
3.7
通讯作者：
Mahoney, Alison E. J.
中科院分区：
文献类型：
--
作者：
McEvoy, Peter M.;Mahoney, Alison E. J.
不确定性不容忍模型最初是在广泛性焦虑症的背景下对焦虑进行解释的。然而，最近的研究发现，不容忍不确定性(IU)可能是跨越焦虑症和抑郁症的跨诊断维持因素。本研究的目的是在寻求治疗的样本(N=328)中，确定IU是否在神经质与各种焦虑症和抑郁症相关症状之间的关系中起中介作用。与以前的研究一致，IU与神经质以及社交恐惧症、惊恐障碍和广场恐惧症、强迫症、广泛性焦虑症和抑郁症的症状显著相关。此外，IU解释了在控制神经质时这些症状测量的独特差异。中介分析表明，IU是神经质和所有症状测量之间的重要部分中介，即使在控制其他障碍的症状时也是如此。更具体地说，对未来不确定性的预期焦虑(前瞻性焦虑)部分中介了神经质与广泛性焦虑症(即担忧)和强迫症症状之间的关系，而面对不确定性时的不作为(抑制性焦虑)部分中介了神经质与社交焦虑、惊恐障碍和广场恐怖症以及抑郁症状之间的关系。索贝尔的测试表明，所有假设的冥想路径都与显著的间接影响有关，尽管对于焦虑的中介效应比其他症状更强。讨论了这些发现对焦虑症和抑郁症治疗的潜在意义。
The Intolerance of Uncertainty Model was initially developed as an explanation for worry within the context of generalized anxiety disorder. However, recent research has identified intolerance of uncertainty (IU) as a possible transdiagnostic maintaining factor across the anxiety disorders and depression. The aim of this study was to determine whether IU mediated the relationship between neuroticism and symptoms related to various anxiety disorders and depression in a treatment-seeking sample (N=328). Consistent with previous research, IU was significantly associated with neuroticism as well as with symptoms of social phobia, panic disorder and agoraphobia, obsessive-compulsive disorder, generalized anxiety disorder, and depression. Moreover, IU explained unique variance in these symptom measures when controlling for neuroticism. Mediational analyses showed that IU was a significant partial mediator between neuroticism and all symptom measures, even when controlling for symptoms of other disorders. More specifically, anxiety in anticipation of future uncertainty (prospective anxiety) partially mediated the relationship between neuroticism and symptoms of generalized anxiety disorder (i.e. worry) and obsessive-compulsive disorder, whereas inaction in the face of uncertainty (inhibitory anxiety) partially mediated the relationship between neuroticism and symptoms of social anxiety, panic disorder and agoraphobia, and depression. Sobel's test demonstrated that all hypothesized meditational pathways were associated with significant indirect effects, although the mediation effect was stronger for worry than other symptoms. Potential implications of these findings for the treatment of anxiety disorders and depression are discussed.