Cystic struma ovarii: a frequently unrecognized tumor. A report of 20 cases.
Cystic struma ovarii: a frequently unrecognized tumor. A report of 20 cases.
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卵巢囊性甲状腺肿：一种经常未被识别的肿瘤。
DOI：
10.1097/00000478-199408000-00004
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Robert E. Scully
中科院分区：
文献类型：
--
作者：
W. Szyfelbein;Robert H. Young;Robert E. Scully
描述了 20 例 23 至 83 岁（平均 46 岁）女性卵巢囊性甲状腺肿病例。患者有附件肿块的常见体征和症状。肿瘤均为单侧且局限于卵巢，最大尺寸为 2 至 19 厘米（平均 13.5）厘米。十八个是多房的，两个是单房的。它们通常充满透明至绿棕色的液体。显微镜检查显示由纤维隔膜分隔的各种大小的囊肿，在许多区域中表现出非特异性，但在所有病例中至少含有少量甲状腺滤泡。囊肿通常衬有非特异性外观的扁平至立方形上皮细胞。许多区域缺乏甲状腺滤泡以及囊肿内壁上皮细胞的非特异性外观常常导致卵巢甲状腺肿的诊断被忽视。除了间隔中的甲状腺滤泡之外，正确诊断的线索还包括少数病例中存在较大区域的典型甲状腺肿，以及三例病例中与皮样囊肿的相关性。甲状腺球蛋白的免疫组织化学染色证实了所有三个病例中肿瘤的性质。当检查多房或单房囊性卵巢肿瘤（其特征与其他肿瘤类型的特征不明显）时，应考虑囊性甲状腺肿的诊断，并应仔细检查甲状腺滤泡以确定诊断。在有问题的病例中，可能需要对甲状腺球蛋白进行免疫组织化学染色来确定诊断。
Twenty cases of cystic struma ovarii in women aged 23 to 83 (average, 46) years are described. The patients had the usual signs and symptoms of an adnexal mass. The tumors, all of which were unilateral and confined to the ovary, ranged from 2 to 19 (average, 13.5) cm in greatest dimension. Eighteen were multilocular, two unilocular. They were typically filled with clear to green-brown fluid. Microscopic examination showed cysts of various sizes separated by fibrous septa, which in many areas appeared nonspecific, but in all the cases contained at least small numbers of thyroid follicles. The cysts were typically lined by nonspecific-appearing, flat to cuboidal epithelial cells. The paucity of thyroid follicles in many areas and the nonspecific appearance of the epithelial cells lining the cysts often caused the diagnosis of struma ovarii to be overlooked. Clues to the correct diagnosis, in addition to the thyroid follicles in the septa, included the presence of larger areas of typical struma in a few cases and the association with a dermoid cyst in three cases. Immunohistochemical staining for thyroglobulin confirmed the nature of the tumor in all three cases in which it was performed. The diagnosis of cystic struma should be entertained when examining a multilocular or unilocular cystic ovarian neoplasm whose features are not obviously those of another tumor type, and a careful search for thyroid follicles should be undertaken to establish the diagnosis. In problematic cases, immunohistochemical staining for thyroglobulin may be required to establish the diagnosis.