A histomorphometric analysis of the alveolar bone resorption process in calcium-deficient rats.
A histomorphometric analysis of the alveolar bone resorption process in calcium-deficient rats.
复制标题
缺钙大鼠牙槽骨吸收过程的组织形态计量学分析。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
H. Amano
中科院分区：
文献类型：
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作者：
H. Amano
为建立实验性牙槽骨吸收模型，观察了低钙饮食大鼠牙槽骨的形态变化。雄性Wistar大鼠(体重70~85g)采用配对饲喂技术，分别饲喂低钙饲料(钙0.05%，磷0.35%)和对照饲料(钙0.5%，磷0.35%)。每隔3、6、9、20d处死大鼠。对照组和低钙组的生长速度无明显差异。低钙组大鼠第3天骨面积明显减少，实验结束时骨面积逐渐减少至对照组的46%。实验早期松质骨有明显的骨吸收，之后皮质骨开始吸收。但骨的轮廓和骨的附着率没有改变。在第20天，骨仍保留在三个区域：围绕牙窝的牙槽骨本身，少数松质骨和一层薄壁状皮质骨。这些结果表明，牙槽骨吸收的过程与牙齿咬合功能所产生的机械力有关，该实验模型可用于研究牙槽骨吸收和牙槽骨紊乱的机制。
The present study was carried out to investigate the morphological changes in the alveolar bone in rats fed a low calcium diet, in order to establish an experimental model of alveolar bone resorption. Male Wistar rats (70-85 g in body weight) were either fed a low calcium diet (0.05% Ca, 0.35% P) or a control diet (0.5% Ca, 0.35% P) by using a pair feeding technique. The rats were sacrificed at intervals of 3, 6, 9 and 20 days. No difference was found in the growth rate between the control and the low calcium group. In the low calcium group, the bone area significantly reduced at day 3 and progressively decreased to 46% of that of the controls by the end of the experiment. The bone resorption was obvious in the cancellous bone during the early period of the experiment and then the cortical bone was seen to resorb. However, the contour of bone and the rate of bone apposition did not change. At day 20, bone still remained in three regions: the alveolar bone proper that surrounds the tooth sockets, a few cancellous bones and a thin wall-like cortical bone. These results suggest that the process of alveolar bone resorption is related to the mechanical forces induced by the occlusal function of the tooth and, further, that this experimental model might be useful for investigating the mechanism of alveolar bone resorption and disorders of the alveolar bone.
低膳食钙和钙补充剂对未成熟、生长大鼠钙代谢和骨骼的影响。
DOI：
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发表时间：
1988
期刊：
Bone and mineral
影响因子：
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作者：
Thomas,ML;Ibarra,MJ;Solcher,B;Wetzel,S;Simmons,DJ
通讯作者：
Simmons,DJ