Historical and Clinical Experiences of Gene Therapy for Solid Cancers in China.
Historical and Clinical Experiences of Gene Therapy for Solid Cancers in China.
复制标题
中国实体瘤基因治疗的历史和临床经验
作者：
Li B;Gao N;Zhang Z;Chen QM;Li LJ;Li Y
基于现代医学的理论和临床发展，基因治疗已经成为治疗癌症和其他疾病的一种很有前途的策略。自从1989年美国国立卫生研究院进行了第一项授权的基因转移研究以来，基因疗法的实践已经有了近27年的历史。然而，直到最近，基因疗法才在全球范围内被轻易采用。自1998年以来，中国开展了多项基因治疗临床试验，中国的医学研究蓬勃发展。在本文中，我们回顾了中国的基因治疗的历史，重点介绍了治疗方案、给药周期、剂量计算和疗效评价，以期为这一有前途的治疗策略的进一步发展提供更多的信息。
Based on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Health in 1989. However, gene therapy was not readily adopted worldwide, until recently. Several gene therapy clinical trials have been carried out in China since 1998, and medical research in China has flourished. In this report, we review the history of gene therapy in China, focusing on treatment protocol, the administration cycle, dosage calculation, and the evaluation of therapeutic effects, in order to provide more information for the additional development of this promising treatment strategy.