Reprogramming Hox expression in the vertebrate hindbrain: Influence of paraxial mesoderm and rhombomere transposition
Reprogramming Hox expression in the vertebrate hindbrain: Influence of paraxial mesoderm and rhombomere transposition
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DOI：
10.1016/s0896-6273(00)80069-0
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发表时间：
1996-03-01
期刊：
影响因子：
16.2
通讯作者：
Krumlauf, R
中科院分区：
文献类型：
--
作者：
Itasaki, N;Sharpe, J;Krumlauf, R
发育中的脊椎动物后脑由称为菱形节的节段组成，菱形节段表达与指定节段身份有关的Hox基因组合。使用鸡鸡和鸡转基因小鼠移植，我们表明，前到后菱体转位导致一个渐进的后转换和协调诱导新的Hox表达。这表明，后脑可塑性是进化保守的，并意味着菱球可能正在经历不断评估他们的身份。变化的性质取决于移植物的前后位置及其来源。转座体节从特定的轴向水平和发育阶段有一个分级的能力，诱导Hox表达的变化，表明近轴中胚层是一个来源的环境信号负责的可塑性。
The developing vertebrate hindbrain consists of segments known as rhombomeres, which express combinations of Hox genes implicated in specifying segmental identity. Using chick-chick and chick-transgenic mouse graftings, we show that anterior to posterior rhombomere transpositions result in a progressive posterior transformation and coordinate induction of new Hox expression. This shows that hindbrain plasticity is evolutionarily conserved and implies rhombomeres may be undergoing continual assessment of their identities. The nature of the changes is dependent on both the anteroposterior position of the graft and its origin. Transposed somites from specific axial levels and developmental stages have a graded ability to induce changes in Hox expression, indicating that paraxial mesoderm is a source of the environmental signal responsible for the plasticity.