Early-childhood linear growth faltering in low- and middle-income countries.
Early-childhood linear growth faltering in low- and middle-income countries.
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DOI：
10.1038/s41586-023-06418-5
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发表时间：
2023-09
期刊：
影响因子：
64.8
通讯作者：
Ki Child Growth Consortium
中科院分区：
文献类型：
--
作者：
Benjamin-Chung, Jade;Mertens, Andrew;Colford Jr, John M.;Hubbard, Alan E.;van der Laan, Mark J.;Coyle, Jeremy;Sofrygin, Oleg;Cai, Wilson;Nguyen, Anna;Pokpongkiat, Nolan N.;Djajadi, Stephanie;Seth, Anmol;Jilek, Wendy;Jung, Esther;Chung, Esther O.;Rosete, Sonali;Hejazi, Nima;Malenica, Ivana;Li, Haodong;Hafen, Ryan;Subramoney, Vishak;Haggstrom, Jonas;Norman, Thea;Brown, Kenneth H.;Christian, Parul;Arnold, Benjamin F.;Ki Child Growth Consortium
据估计，全球有1.49亿5岁以下儿童发育迟缓(身长比国际生长标准低2个标准差以上)。发育迟缓是线性生长迟缓的一种形式，会增加患病风险、认知发育障碍和死亡率。全球发育迟缓估计依赖于横断面调查，无法提供有关增长迟缓的开始或持续时间的直接信息--这是确定提供预防干预的关键窗口的关键考虑因素。在这里，我们完成了对低收入和中等收入国家(n = 32个队列，52,640名儿童，年龄0-24个月)的纵向研究的汇集分析，使我们能够确定线性增长迟缓的典型开始年龄，并调查早期反复出现的迟缓。发育迟缓的发病率最高的是出生到3个月大的婴儿，在南亚出生时发育迟缓的发生率要高得多。从0到15个月，发育迟缓逆转是罕见的；逆转发育迟缓状态的儿童经常复发，而且出生时发育迟缓儿童的复发率要高得多。早期发病和低反转率表明，要改善儿童的线性成长，将需要对育龄妇女进行生命周期干预，并更加重视对6个月以下儿童的干预。一项对低收入和中等收入国家的纵向研究的汇集分析确定了线性增长步履蹒跚的典型开始年龄，并调查了早期生活中反复出现的步履蹒跚。
Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards). Stunting, a form of linear growth faltering, increases the risk of illness, impaired cognitive development and mortality. Global stunting estimates rely on cross-sectional surveys, which cannot provide direct information about the timing of onset or persistence of growth faltering—a key consideration for defining critical windows to deliver preventive interventions. Here we completed a pooled analysis of longitudinal studies in low- and middle-income countries (n = 32 cohorts, 52,640 children, ages 0–24 months), allowing us to identify the typical age of onset of linear growth faltering and to investigate recurrent faltering in early life. The highest incidence of stunting onset occurred from birth to the age of 3 months, with substantially higher stunting at birth in South Asia. From 0 to 15 months, stunting reversal was rare; children who reversed their stunting status frequently relapsed, and relapse rates were substantially higher among children born stunted. Early onset and low reversal rates suggest that improving children’s linear growth will require life course interventions for women of childbearing age and a greater emphasis on interventions for children under 6 months of age. A pooled analysis of longitudinal studies in low- and middle-income countries identifies the typical age of onset of linear growth faltering and investigates recurrent faltering in early life.
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影响因子：
168.9
作者：
Adair, Linda S.;Fall, Caroline H. D.;Osmond, Clive;Stein, Aryeh D.;Martorell, Reynaldo;Ramirez-Zea, Manuel;Sachdev, Harshpal Singh;Dahly, Darren L.;Bas, Isabelita;Norris, Shane A.;Micklesfield, Lisa;Hallal, Pedro;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
5.4
作者：
Georgiadis, Andreas;Benny, Liza;Woldehanna, Tassew
通讯作者：
Woldehanna, Tassew
影响因子：
7.7
作者：
Christian P;Lee SE;Donahue Angel M;Adair LS;Arifeen SE;Ashorn P;Barros FC;Fall CH;Fawzi WW;Hao W;Hu G;Humphrey JH;Huybregts L;Joglekar CV;Kariuki SK;Kolsteren P;Krishnaveni GV;Liu E;Martorell R;Osrin D;Persson LA;Ramakrishnan U;Richter L;Roberfroid D;Sania A;Ter Kuile FO;Tielsch J;Victora CG;Yajnik CS;Yan H;Zeng L;Black RE
通讯作者：
Black RE
影响因子：
3.4
作者：
de Onis M;Branca F
通讯作者：
Branca F
影响因子：
9.3
作者：
Cumming, Oliver;Arnold, Benjamin F.;Colford, John M., Jr.
通讯作者：
Colford, John M., Jr.