Cingulum White Matter in Young Women at Risk of Depression: The Effect of Family History and Anhedonia
Cingulum White Matter in Young Women at Risk of Depression: The Effect of Family History and Anhedonia
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DOI：
10.1016/j.biopsych.2012.01.022
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发表时间：
2012-08-15
影响因子：
10.6
通讯作者：
Jones, Derek K.
中科院分区：
文献类型：
--
作者：
Keedwell, Paul A.;Chapman, Rosanna;Jones, Derek K.
背景资料：改变的白色物质的微结构，在束不可或缺的情绪调节网络可能会导致严重抑郁症（MDD）的脆弱性。功能磁共振研究的指导下，我们探讨了是否有积极的家族病史的抑郁症（FH+）和快感缺乏症（减少愉悦的能力）与改变白色物质微结构的扣带束和钩束。方法：扩散张量磁共振成像数据采集34名健康女学生志愿者（平均年龄22岁）。排除标准包括其他当前或既往精神疾病、当前抑郁症和当前精神药物治疗。家族史采用既定标准确定。对每个人进行纤维束成像，用于先验感兴趣的束和比较束。平均分数各向异性（FA），微观结构的指数，计算为每个tract.Results：Tracts重建在18 FH+个人和15 FH-个人，谁没有不同的年龄或亚临床抑郁症状。FH+受试者的右侧和左侧扣带束FA比FH-个体低3%至5%（分别为p = 0.012，p = 0.059）。事后分析表明，左侧膝下扣带回的FA降低8%（p = .007）。左右扣带回束的快乐音与FA呈正相关（分别为r = .342，p = .052; r = .477，p = .005），左膝下扣带（r = .500，p = .003）。MDD家族史和亚临床快感缺乏都与双侧扣带束FA减少有关，尤其是在左膝下扣带扣带回白色结构改变与MDD的病因有关。
Background: Altered white matter microstructure in tracts integral to mood regulation networks could underlie vulnerability to major depressive disorder (MDD). Guided by functional magnetic resonance studies, we explored whether a positive family history of MDD (FH+) and anhedonia (reduced capacity for pleasure) were associated with altered white matter microstructure in the cingulum bundles and uncinate fasciculi.Methods: Diffusion tensor magnetic resonance imaging data were acquired on 34 healthy female student volunteers (mean age 22 years). Exclusion criteria included other current or previous psychiatric disorder, current depression, and current psychotropic medication. Family history was determined using established criteria. Fiber tractography was performed for each individual for a priori tracts of interest and a comparison tract. Mean fractional anisotropy (FA), an index of microstructure, was calculated for each tract.Results: Tracts were reconstructed in 18 FH+ individuals and 15 FH-individuals, who did not differ by age or subclinical depressive symptoms. FH+ subjects had 3% to 5% lower FA in the right and left cingulum bundles than FH-individuals (p = .012, p = .059, respectively). Post hoc analysis demonstrated 8% lower FA in the left subgenual cingulate (p = .007). Hedonic tone correlated positively with FA in the right and left cingulum bundles (r = .342, p = .052; r = .477, p = .005, respectively), and the left subgenual cingulum (r = .500, p = .003).Conclusions: Both family history of MDD and subclinical anhedonia are associated with reduced FA in the bilateral cingulum bundles, particularly in the left subgenual cingulum. Altered cingulum white matter architecture is implicated in the etiology of MDD.