Proteomic analysis of post translational modifications in cyanobacteria
Proteomic analysis of post translational modifications in cyanobacteria
复制标题
蓝藻翻译后修饰的蛋白质组学分析
DOI：
10.1016/j.jprot.2015.07.037
复制
发表时间：
2016
影响因子：
3.3
通讯作者：
Ge Feng
中科院分区：
文献类型：
--
作者：
Xiong Qian;Chen Zhuo;Ge Feng
蓝细菌是革兰氏阴性细菌的一个多样化的群体，并且是唯一能够进行产氧光合作用的原核生物。最近，蓝细菌因其在全球碳和氮循环中的关键作用以及生产清洁和可再生生物燃料的能力而引起了人们的极大兴趣。为了在各种环境条件下生存，蓝藻已经发展了一个复杂的信号转导网络来感知环境信号并实施适应性变化。翻译后修饰系统在蓝藻的信号转导网络中起着重要的调控作用。对蛋白质翻译模块的系统研究有助于全面描述蓝藻中的蛋白质种类，并阐明每种蛋白质种类的潜在生物学作用。虽然在蓝藻中进行的PTM的蛋白质组学研究是有限的，这些数据提供了线索，以阐明其复杂的传感机制，有助于其进化和生态的成功。本文综述了蓝藻PTM蛋白质组学的研究现状和最新研究成果，并对蓝藻PTM蛋白质组学研究的新进展和应用前景进行了讨论。最后讨论了蓝藻蛋白质组学研究的挑战、机遇和前景。
Cyanobacteria are a diverse group of Gram-negative bacteria and the only prokaryotes capable of oxygenic photosynthesis. Recently, cyanobacteria have attracted great interest due to their crucial roles in global carbon and nitrogen cycles and their ability to produce clean and renewable biofuels. To survive in various environmental conditions, cyanobacteria have developed a complex signal transduction network to sense environmental signals and implement adaptive changes. The post-translational modifications (PTMs) systems play important regulatory roles in the signaling networks of cyanobacteria. The systematic investigation of PTMs could contribute to the comprehensive description of protein species and to elucidate potential biological roles of each protein species in cyanobacteria. Although the proteomic studies of PTMs carried out in cyanobacteria were limited, these data have provided clues to elucidate their sophisticated sensing mechanisms that contribute to their evolutionary and ecological success. This review aims to summarize the current status of PTM studies and recent publications regarding PTM proteomics in cyanobacteria, and discuss the novel developments and applications for the analysis of PTMs in cyanobacteria. Challenges, opportunities and future perspectives in the proteomics studies of PTMs in cyanobacteria are also discussed.