Sensitivity and Specificity of a Urine Circulating Anodic Antigen Test for the Diagnosis of Schistosoma haematobium in Low Endemic Settings
Sensitivity and Specificity of a Urine Circulating Anodic Antigen Test for the Diagnosis of Schistosoma haematobium in Low Endemic Settings
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DOI：
10.1371/journal.pntd.0003752
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发表时间：
2015-05-01
影响因子：
3.8
通讯作者：
van Dam, Govert J.
中科院分区：
文献类型：
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作者：
Knopp, Stefanie;Corstjens, Paul L. A. M.;van Dam, Govert J.
背景消除血吸虫病这一公共卫生问题并在选定地区阻断传播是世界卫生组织2025年的主要目标。常规的寄生虫学方法对于检测光强度感染不敏感。需要高灵敏度和特异性的技术，以便在低传播环境中进行准确诊断并验证消除。我们确定了在坦桑尼亚桑给巴尔低发病率环境中，尿基上转换磷-侧流循环阳极抗原（UCP-LF CAA）检测用于埃及血吸虫病诊断的准确性。嗜血杆菌流行率为
BackgroundElimination of schistosomiasis as a public health problem and interruption of transmission in selected areas are key goals of the World Health Organization for 2025. Conventional parasitological methods are insensitive for the detection of light-intensity infections. Techniques with high sensitivity and specificity are required for an accurate diagnosis in low-transmission settings and verification of elimination. We determined the accuracy of a urine-based up-converting phosphor-lateral flow circulating anodic antigen (UCP-LF CAA) assay for Schistosoma haematobium diagnosis in low-prevalence settings in Zanzibar, Tanzania.MethodologyA total of 1,740 urine samples were collected in 2013 from children on Pemba Island, from schools where the S. haematobium prevalence was