Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms
Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms
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DOI：
10.3389/fmicb.2015.01529
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发表时间：
2016-01-14
影响因子：
5.2
通讯作者：
Skaltsounis, Alexios L.
中科院分区：
文献类型：
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作者：
Karygianni, Lamprini;Al-Ahmad, Ali;Skaltsounis, Alexios L.
龋齿和牙周炎等口腔疾病主要由微生物生物膜引起。在抗微生物耐药性方面，抗生素治疗已达到极限，利用天然植物化学物质的新治疗措施目前是研究的重点。因此，本系统综述批判性地阐述了各种药用植物对体外、离体和原位形成的多种口腔生物膜的抗菌作用。检索在三个英文数据库（PubMed、EMBASE、CAMbase）以及五种德国期刊从创刊到2014年10月10日的电子档案中进行，检索词为“（植物提取物或草药提取物或植物或草药）AND（口腔生物膜或牙齿生物膜或牙菌斑或口腔疾病或牙科疾病）”。汇总数据根据系统综述和荟萃分析优先报告条目指南（PRISMA）进行评估。最初确定了1848篇文章，其中筛选了585篇全文文章，对149篇文章重新评估是否符合资格，最终14篇文章符合所有纳入标准。14份报告的数据显示，从葡萄、松属、中果咖啡、茶树、蔓越莓、五倍子、巴西苏木、草莓番石榴、具有代表性的巴西植物以及麦卢卡蜂蜜中获得的植物提取物具有增强的抗黏附和抗生物膜活性。总体而言，基于草药的治疗与各种多种口腔生物膜的清除率之间呈现正相关。在这种情况下，将受草药启发的治疗方法纳入甚至取代传统的牙科治疗方案，能够对口腔生物膜进而对牙科疾病进行有效的抗菌控制。
Oral diseases such as caries and periodontitis are mainly caused by microbial biofilms. Antibiotic therapy has reached its limits with regard to antimicrobial resistance, and new therapeutic measures utilizing natural phytochemicals are currently a focus of research. Hence, this systematic review provides a critical presentation of the antimicrobial effects of various medicinal herbs against in vitro, ex vivo, and in situ formed multispecies oral biofilms. Searches were performed in three English databases (PubMed, EMBASE, CAMbase) and the electronic archives of five German journals from the times of their establishment until October 10th, 2014, with the search terms "(plant extracts OR herbal extracts OR plant OR herb) AND (oral bio film OR dental bio film OR dental plaque OR oral disease OR dental disease)." The pooled data were assessed according to Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines (PRISMA). Initially, 1848 articles were identified, out of which 585 full-text articles were screened, 149 articles were reevaluated for eligibility and finally, 14 articles met all inclusion criteria. The data of 14 reports disclosed enhanced antiadhesive and antibiofilm activity by the plant extracts obtained from Vitis vinifera, Pinus spp., Coffee canephora, Camellia sinensis, Vaccinium macrocarpon, Galla chinensis, Caesalpinia ferrea Martius, Psidium cattleianum, representative Brazilian plants and manuka honey. Overall, a positive correlation was revealed between herb based therapies and elimination rates of all types of multispecies oral biofilms. In that context, integrating or even replacing conventional dental therapy protocols with herbal-inspired treatments can allow effective antimicrobial control of oral biofilms and thus, dental diseases.