Novel insights on interactions between folate and lipid metabolism.
Novel insights on interactions between folate and lipid metabolism.
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DOI：
10.1002/biof.1154
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发表时间：
2014-05
期刊：
影响因子：
6
通讯作者：
Jacobs, Rene L.
中科院分区：
文献类型：
--
作者：
da Silva, Robin P.;Kelly, Karen B.;Al Rajabi, Ala;Jacobs, Rene L.
叶酸是维持ADOMet依赖甲基化所必需的B族维生素。肝脏负责许多甲基化反应，这些甲基化反应用于蛋白质的翻译后修饰、DNA的甲基化以及激素、肌酸、肉碱和卵磷脂的合成。甲基化能力受损的情况，包括叶酸缺乏，与磷脂酰胆碱合成受损有关，导致非酒精性脂肪性肝病和脂肪性肝炎。此外，叶酸摄入量和叶酸状态与涉及脂肪代谢、肥胖和代谢综合征的基因表达的变化有关。在这篇综述中，我们对叶酸与脂类代谢的关系进行了深入的探讨，并对脂类相关叶酸研究的未来进行了展望。《2013生物因素》，40(3)：277-283,2014
Folate is an essential B vitamin required for the maintenance of AdoMet-dependent methylation. The liver is responsible for many methylation reactions that are used for post-translational modification of proteins, methylation of DNA, and the synthesis of hormones, creatine, carnitine, and phosphatidylcholine. Conditions where methylation capacity is compromised, including folate deficiency, are associated with impaired phosphatidylcholine synthesis resulting in non-alcoholic fatty liver disease and steatohepatitis. In addition, folate intake and folate status have been associated with changes in the expression of genes involved in lipid metabolism, obesity, and metabolic syndrome. In this review, we provide insight on the relationship between folate and lipid metabolism, and an outlook for the future of lipid-related folate research. © 2013 BioFactors, 40(3):277–283, 2014
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