Investigation of oxidative stress and dietary habits in Mongolian people, compared to Japanese people
Investigation of oxidative stress and dietary habits in Mongolian people, compared to Japanese people
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DOI：
10.1186/1743-7075-3-21
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发表时间：
2006-06-07
影响因子：
4.5
通讯作者：
Purvee, Baatar
中科院分区：
文献类型：
--
作者：
Komatsu, Fumio;Kagawa, Yasuo;Purvee, Baatar
研究背景：蒙古族的平均寿命男性为62岁，女性为69岁。寿命比日本人短16年左右。蒙古族人一般吃肉类、脂肪和乳制品，但较少吃蔬菜和水果。为此，我们调查了蒙古族人群的氧化应激状况和饮食习惯。共入组164例健康受试者（24 - 66岁）。作为活性氧物质的标志物，使用d-ROM测试测量活性氧代谢物（ROM）的水平。使用香川营养大学建立的食物频率问卷进行饮食习惯的访谈。结果：穆伦人的ROM水平为429.7 +/- 95.2卡尔U，而日本人（n = 220，21 - 98岁）显示为335.3 +/- 59.8（p < 0.001）。血清丙二醛修饰的低密度脂蛋白胆固醇和尿8-羟基脱氧鸟苷水平也很高。ROM水平与体脂率相关，与握力呈负相关。45岁以上的受试者的握力下降速度比年龄匹配的日本人更快。与日本人相比，穆伦人食用更多的肉类、脂肪、牛奶、面粉和奶制品，但蔬菜和水果较少。血清维生素A和E水平与日本参考文献相同，但维生素C水平较低。结论：穆伦人可能处于高氧化应激状态，这可能与早期衰老和多种疾病有关，最终导致其寿命较短。为了增加抗氧化能力和抑制ROM的过度生产，建议摄入抗氧化食物。
Background: The average life span of Mongolians is 62 years for males and 69 years for females. This life span is about 16 years shorter than that of Japanese. Mongolian people generally eat meat, fat and diary products but less vegetables or fruit. Thus, we investigated the state of oxidative stress and dietary habits of Mongolians.Methods: The investigation was performed in Murun city in the northwest area of Mongolia. A total of 164 healthy subjects ( 24 - 66 y) were enrolled. As a marker of reactive oxygen species, the levels of reactive oxygen metabolites ( ROM) were measured using the d-ROM test. Interviews about dietary habits were performed using the Food Frequency Questionnaire established by the Kagawa Nutrition University.Results: ROM levels were 429.7 +/- 95.2 Carr U for Murun subjects, whereas Japanese people (n = 220, 21 - 98 y) showed 335.3 +/- 59.8 ( p < 0.001). The levels of serum malondialdehyde-modified low-density lipoprotein-cholesterol and urinary 8-hydroxydeoxyguanosine were also high. ROM levels correlated with body fat ratio and inversely correlated with handgrip strength. Handgrip strength in the subjects over 45 years decreased more rapidly than that of age-matched Japanese. Murun subjects ate larger amounts of meat, fat, milk and flour and dairy products than Japanese, but less vegetables or fruit. Serum vitamin A and E levels were the same as Japanese references, but vitamin C levels were lower.Conclusion: Murun subjects may be in high oxidative stress, which may have a relationship with early ageing and several diseases, ultimately resulting in their short life span. In order to increase antioxidant capacity and suppress overproduction of ROM, antioxidant food intake is recommended.