Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount
Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount
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DOI：
10.1152/japplphysiol.01314.2006
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Kraus, William E.
中科院分区：
文献类型：
--
作者：
Slentz, Cris A.;Houmard, Joseph A.;Kraus, William E.
运动对脂蛋白有有益的影响。很少有人知道这种效果持续多久，或者是否受益的持续时间受到训练强度或数量的影响。久坐不动的超重受试者（n = 240）被随机分为6个月对照组或三个运动组之一：1）高量/高强度运动; 2）低量/高强度运动;或3）低量/中等强度运动。训练包括逐渐增加运动量，然后在规定的水平上进行6个月的运动。运动包括跑步机、椭圆机和固定自行车。计算每名受试者每周消耗规定千卡所需的分钟数（两个低量组均为14 kcal.kg体重（-1）.wk（-1）;高量组为23 kcal. kg体重（-1）.wk（-1））。三组的平均依从性为83-92%;高量/高强度组、低量/高强度组和低量/中等强度组的每周分钟数分别为207、125和203，每周会话数分别为3.6、2.9和3.5。在基线、运动停止后24小时、5天和15天获得血浆。持续不活动导致低密度脂蛋白（LDL）颗粒数量、小密度LDL和LDL胆固醇显著增加。适量的运动训练可以防止这种恶化。中等强度而非剧烈强度的运动导致停训15天后极低密度脂蛋白（VLDL）-甘油三酯持续降低（P < 0.05）。高剂量组在高密度脂蛋白（HDL）胆固醇，HDL颗粒大小和大HDL水平方面有显着改善，并在运动停止后持续15天。总之，缺乏身体活动对脂蛋白代谢有深远的负面影响。适度的锻炼可以防止这种情况。中等强度但非剧烈强度的运动导致持续的VLDL-甘油三酯降低。每天30分钟的剧烈运动，如慢跑，对HDL代谢有持续的有益影响。
Exercise has beneficial effects on lipoproteins. Little is known about how long the effects persist with detraining or whether the duration of benefit is effected by training intensity or amount. Sedentary, overweight subjects ( n = 240) were randomized to 6-mo control or one of three exercise groups: 1) high-amount/vigorous-intensity exercise; 2) low-amount/vigorous-intensity exercise; or 3) low-amount/moderate-intensity exercise. Training consisted of a gradual increase in amount of exercise followed by 6 mo of exercise at the prescribed level. Exercise included treadmill, elliptical trainer, and stationary bicycle. The number of minutes necessary to expend the prescribed kilocalories per week ( 14 kcal.kg body wt(-1).wk(-1) for both low-amount groups; 23 kcal.kg body wt(-1).wk(-1) for high-amount group) was calculated for each subject. Average adherence was 83-92% for the three groups; minutes per week were 207, 125, and 203 and sessions per week were 3.6, 2.9, and 3.5 for high-amount/vigorous-intensity, low-amount/vigorous intensity, and low-amount/moderate-intensity groups, respectively. Plasma was obtained at baseline, 24 h, 5 days, and 15 days after exercise cessation. Continued inactivity resulted in significant increases in low-density lipoprotein ( LDL) particle number, small dense LDL, and LDL-cholesterol. A modest amount of exercise training prevented this deterioration. Moderate-intensity but not vigorous-intensity exercise resulted in a sustained reduction in very-low-density lipoprotein ( VLDL)-triglycerides over 15 days of detraining ( P < 0.05). The high-amount group had significant improvements in high-density lipoprotein ( HDL)-cholesterol, HDL particle size, and large HDL levels that were sustained for 15 days after exercise stopped. In conclusion, physical inactivity has profound negative effects on lipoprotein metabolism. Modest exercise prevented this. Moderate-intensity but not vigorous-intensity exercise resulted in sustained VLDL-triglyceride lowering. Thirty minutes per day of vigorous exercise, like jogging, has sustained beneficial effects on HDL metabolism.