Saccharin does not bind to DNA of liver or bladder in the rat.
Saccharin does not bind to DNA of liver or bladder in the rat.
复制标题
糖精不与大鼠肝脏或膀胱的 DNA 结合。
DOI：
10.1016/0009-2797(77)90036-9
复制
发表时间：
1977
影响因子：
5.1
通讯作者：
C. Schlatter
中科院分区：
文献类型：
--
作者：
W. Lutz;C. Schlatter
研究发现，在第一代和第二代雄性大鼠中，终身喂养含5%糖精的饮食后，糖精会诱发膀胱肿瘤[1]。另一方面，尽管长期广泛使用，但在较低剂量和人类食用甜味剂的流行病学研究中，没有明确的证据表明其具有致癌活性[2]。这一争议促使我们研究糖精与完整哺乳动物有机体中 DNA 的相互作用。大多数已知的化学致癌物都会与 DNA 发生共价结合 [3]，由此产生的损伤可能导致突变。尚未发现糖精具有致突变性 [4, 5]，并且本研究表明它也不与雄性大鼠的肝脏或膀胱 DNA 发生共价结合。因此，肿瘤诱导可能是由于膀胱的继发性损伤。
Saccharin was found to induce bladder tumours in male rats of the first and the second generation after life-long feeding of a diet containing 5% saccharin [1]. On the other band, with lower doses, and in epidemiological sturlies on the human consumption as sweetening agent there is no clear evidence for a carcinogenic activity despite the long and widespread use [2]. This controversy prompted us to investigate the interaction of saccharin with DNA in an intact mammalian organism. Most of the known chemical carcinogens undergo a covalent binding to DNA [3], and the resulting darnage can lead to a mutation. Saccharin has not been found to be mutagenic [4, 5] and the present study shows that it does not undergo a covalent binding to DNA of the liver or the bladder of male rats either. The tumor induction is therefore probably due to a secondary darnage to the bladder.