The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients
The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients
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DOI：
10.1016/j.eplepsyres.2006.01.001
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发表时间：
2006-04-01
影响因子：
2.2
通讯作者：
Stufflebeam, SM
中科院分区：
文献类型：
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作者：
Knake, S;Halgren, E;Stufflebeam, SM
目标：为了评估的敏感性，同时全头306通道脑磁图（MEG）/70电极脑电图记录检测发作间期癫痫样活动（IED）在一个前瞻性的，连续的队列的患者与药物难治性癫痫，被认为是候选人为epilepsy surgery.Methods：70例患者进行了前瞻性评估，同时记录MEG/EEG。所有患者均为手术候选人或考虑进行侵入性EEG监测，并在三级癫痫中心进行了广泛的术前评估。MEG和EEG的原始痕迹分别由两个独立的reviewers.Results：MEG数据无法进行评估，由于过度的磁伪影在三名患者（4%）。在其余67例患者中，分析原始数据，MEG检测IED的总体灵敏度为72%（48/67例患者），EEG为61%（41/67例患者）。在13%（9/67例患者）中，仅记录了MEG IED，而在3%（2/67例患者）中，仅记录了EEG IED。结论：306导MEG记录IED的敏感性与EEG相似，具有互补性。在三分之一的EEG阴性患者中，MEG可以预期记录IED，特别是在外侧新皮质癫痫和/或皮质发育不良的情况下。(c)2006 Elsevier B. V.保留所有权利。
Obective: To evaluate the sensitivity of a simultaneous whole-head 306-channel magnetoencephalography (MEG)/70-electrode EEG recording to detect interictal epileptiform activity (IED) in a prospective, consecutive cohort of patients with medically refractory epilepsy that were considered candidates for epilepsy surgery.Methods: Seventy patients were prospectively evaluated by simultaneously recorded MEG/EEG. All patients were surgical candidates or were considered for invasive EEG monitoring and had undergone an extensive presurgical evaluation at a tertiary epilepsy center. MEG and EEG raw traces were analysed individually by two independent reviewers.Results: MEG data could not be evaluated due to excessive magnetic artefacts in three patients (4%). In the remaining 67 patients, the overall sensitivity to detect IED was 72% (48/67 patients) for MEG and 61% for EEG (41/67 patients) analysing the raw data. In 13% (9/67 patients), MEG-only IED were recorded, whereas in 3% (2/67 patients) EEG-only IED were recorded. The combined sensitivity was 75% (50/67 patients).Conclusion: Three hundred and six-channel MEG has a similarly high sensitivity to record IED as EEG and appears to be complementary. In one-third of the EEG-negative patients, MEG can be expected to record IED, especially in the case of lateral neocortical epilepsy and/or cortical dysplasia. (c) 2006 Elsevier B.V. All rights reserved.