Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain
Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain
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DOI：
10.1021/nl049126a
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发表时间：
2004-09-01
期刊：
影响因子：
10.8
通讯作者：
Wang, LV
中科院分区：
文献类型：
--
作者：
Wang, YW;Xie, XY;Wang, LV
这项研究证明了在体内使用纳米壳作为光声断层扫描的新型对比度增强剂的可行性。采用深穿透近红外光对大鼠大脑脉管系统中循环的聚乙二醇涂层纳米壳的体内分布进行成像。这些图像是在连续三次施用纳米壳后拍摄的，显示脑血管中的光学吸收逐渐增强高达 63%。随后对纳米壳从血液中的清除进行成像，持续大约在给药后6小时。
This study demonstrates the feasibility of using nanoshells in vivo as a new contrast-enhancing agent for photoacoustic tomography. Deep penetrating near-infrared light was employed to image the in vivo distribution of poly(ethylene glycol)-coated nanoshells circulating in the vasculature of a rat brain. The images, captured after three sequential administrations of nanoshells, present a gradual enhancement of the optical absorption in the brain vessels by up to 63%. Subsequent clearance of the nanoshells from the blood was imaged for similar to6 h after the administrations.