Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.
Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.
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巴拉圭药用植物的化学和药物研究。
DOI：
10.1021/np50056a033
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发表时间：
1988
影响因子：
5.1
通讯作者：
I. Basualdo
中科院分区：
文献类型：
--
作者：
H. Ueno;Syunji Horie;Yumiko Nishi;H. Shogawa;Masaru Kawasaki;Shoichi Suzuki;Toshimitsu Hayashi;M. Arisawa;M. Shimizu;Masao Yoshizaki;Naokata Morita;L. H. Berganza;Esteban A. Ferro;I. Basualdo
Paraparai mi，Phyllantbus niruri L.（大戟科），传统上用于治疗尿路结石疾病，并作为利尿剂在巴拉圭。对60多种药用植物进行生物活性筛选试验，发现“帕拉米”的70%EtOH提取物对血管紧张素转换酶（ACE）有抑制作用。在我们的研究的继续中，发现药用植物的正丁醇提取物比乙醇提取物具有更高的活性。ACE是一种二肽基羧肽酶，通过催化一种重要的反应在血压调节中起重要作用。目前已报道了几种植物来源的ACE抑制剂。此前，Inokuchi及其同事研究了来自中国生药的ACE抑制剂（2，3），并报道了来自槟榔种子的抑制剂（4）。我们还报道了天然产物粗提物对ACE的抑制活性（5）。最近，Uchida等人从“大黄”中分离出一些缩合单宁作为ACE抑制剂（6），Kameda等人从“大黄”中分离出一些缩合单宁作为ACE抑制剂（6）。报道了（+）-儿茶素作为来自狭叶栎的抑制剂（7）。P. niruri有
“Paraparai mi,” Phyllantbus niruri L.(Euphorbiaceae), has traditionally been used for the treatment of urolitic disease and as a diuretic in Paraguay. In the screening tests for biological activityof about 60 Paraguayan medicinal plants, however, the 70% EtOH extract of “paraparai mi” was found to have in-hibitory activity against angiotensinconverting enzyme (ACE). In continua-tion of our studies, the»-BuOH extract of the medicinal plant was found to have higher activity than the EtOH extract. ACE is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation by catalyzing an im-portant reaction. Several inhibitors of ACE from plant sources have been re-ported. Previously, Inokuchi and co-workers investigated ACE inhibitors ex-tracted from Chinese crude drugs (2, 3) and reported the inhibitors from the seeds of Areca catechu (4). We also re-ported inhibitory activity of crude ex-tracts from natural products on ACE (5). Recently, Uchida et al. isolated some condensed tannins from “rhei rhizoma” as ACE inhibitors (6), and Kameda etal. reported (+)-catechin as the inhibitor from Quercus stenophylla (7). P. niruri has