Temperature at birth, coronary heart disease, and insulin resistance: cross sectional analyses of the British women's heart and health study
Temperature at birth, coronary heart disease, and insulin resistance: cross sectional analyses of the British women's heart and health study
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DOI：
10.1136/hrt.2002.009548
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发表时间：
2004-04-01
期刊：
影响因子：
5.7
通讯作者：
Ebrahim, S
中科院分区：
文献类型：
--
作者：
Lawlor, DA;Smith, GD;Ebrahim, S
目的：评价出生前后平均室外温度与胰岛素抵抗和晚年冠心病的关系。设计：横断面研究。背景：23个英国城镇。参与者：4286名60-79岁的女性。主要观察指标：冠心病和胰岛素抵抗。结果：出生在最冷月份的妇女冠心病患病率最高：出生在最冷月份的妇女与其他三个季度出生的妇女相比，年龄调整后的优势比为1.24(95%可信区间为1.03到1.50)。出生时寒冷的室外温度也与胰岛素抵抗增加、甘油三酯浓度增加和肺功能较差有关。出生时寒冷的室外温度与冠心病之间的联系只能由已知的冠心病危险因素部分解释：完全调整(针对所有测量的潜在解释因素和混合因素)优势比1.19(95%可信区间0.95至1.48)。出生时低温与冠心病的关联在父亲是失业的或在儿童时期处于体力社会阶层的人中最为明显，而在儿童时期来自非体力社会阶层的人中不存在。结论：出生时室外温度寒冷与冠心病、胰岛素抵抗、血脂异常和肺功能不良有关。需要进一步的研究来确定这一发现是否反映了发生在宫内发育晚期或出生后早期的事件。
Objective: To assess the association of mean outdoor temperature around the time of birth with insulin resistance and coronary heart disease in later life.Design: Cross sectional study.Setting: 23 British towns.Participants: 4286 women aged 60 - 79 years.Main outcome measures: Coronary heart disease and insulin resistance.Results: Coronary heart disease prevalence was greatest among women born during the coldest months: the age adjusted odds ratio comparing women born in the coldest quarter of monthly outdoor birth temperatures with the remaining three quarters was 1.24 (95% confidence interval (CI) 1.03 to 1.50). Cold outdoor temperature at birth was also associated with increased insulin resistance, increased triglyceride concentrations, and poorer lung function. The link between cold outdoor temperature at birth and coronary heart disease was only partly explained by known coronary disease risk factors: fully adjusted ( for all measured potential explanatory and confounding factors) odds ratio 1.19 ( 95% CI 0.95 to 1.48). The association between cold temperature at birth and coronary heart disease was most pronounced among those whose fathers were either unemployed or in manual social classes when the participants were children, and was non-existent in those from non-manual social classes in childhood.Conclusions: Cold outdoor temperature at birth is associated with increased coronary heart disease, insulin resistance, dyslipidaemia, and poor lung function. Further research is needed to determine whether this finding reflects events occurring late in the third trimester of intrauterine growth or early in the postnatal period.