BRONCHOGENIC-CARCINOMA IN PATIENTS YOUNGER THAN 40 YEARS
BRONCHOGENIC-CARCINOMA IN PATIENTS YOUNGER THAN 40 YEARS
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DOI：
10.1016/s0003-4975(10)60678-9
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发表时间：
1983-01-01
影响因子：
4.6
通讯作者：
BERNATZ, PE
中科院分区：
文献类型：
--
作者：
PEMBERTON, JH;NAGORNEY, DM;BERNATZ, PE
据报道，支气管源性癌在年轻人中比在老年人中更迅速致死。研究人员检查了年轻患者是否经历了更致命的肺癌形式，或者是否有其他因素可能导致生存率低。我们回顾了1956年至1976年间梅奥诊所确诊的113例40岁以下组织学证实的支气管癌患者的记录。104名患者（92%）在诊断前的症状平均持续时间为4个月。该疾病在9例患者中分为I期，6例为II期，98例为III期。56例患者行开胸手术。17例治愈，14例缓解；25例病变不能切除。治愈性切除后的1年和2年生存率分别为71%和35%，姑息性切除后的1年和2年生存率分别为79%和28%。I期患者1年生存率为82%，II期为40%，III期为26%。如果不切除，只有16%的患者存活1年或更长时间。这组年轻患者表现为疾病晚期。
Bronchogenic carcinoma is reported to be more rapidly fatal in young persons than in older persons. Whether young patients experience a more virulent form of lung cancer or whether other factors might contribute to poor survival was examined. The records were reviewed of 113 Mayo Clinic patients younger than 40 yr with histologically proven bronchogenic carcinoma diagnosed between 1956 and 1976. One hundred four patients (92%) had symptoms for a mean duration of 4 mo. before diagnosis. The disease was categorized as stage I in 9 patients, stage II in 6, and stage III in 98. Fifty-six patients underwent thoracotomy. The procedure was curative in 17 and palliative in 14; in 25, the lesion was unresectable. Respective 1 yr and 2 yr survivals were 71% and 35% after curative resection and 79% and 28% after palliative resection. The 1 yr survival was 82% for patients in stage I, 40% for stage II, and 26% for stage III. Without resection, only 16% of patients lived 1 yr or longer. Advanced disease at presentation characterized this group of young patients.