Systemic inflammatory response syndrome in tissue-type plasminogen activator-treated patients is associated with worse short-term functional outcome.
Systemic inflammatory response syndrome in tissue-type plasminogen activator-treated patients is associated with worse short-term functional outcome.
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DOI：
10.1161/strokeaha.113.001371
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发表时间：
2013-08
期刊：
影响因子：
8.3
通讯作者：
Miller DW
中科院分区：
文献类型：
--
作者：
Boehme AK;Kapoor N;Albright KC;Lyerly MJ;Rawal PV;Bavarsad Shahripour R;Alvi M;Houston JT;Sisson A;Beasley TM;Alexandrov AW;Alexandrov AV;Miller DW
全身炎症反应（SIRS）是一种全身性炎症状态。本研究的主要目的是确定SIRS和非SIRS IV tPA治疗患者的结局是否存在差异。回顾性分析了连续性患者在入院期间SIRS的证据。SIRS定义为存在两种或两种以上：体温<36° C或>38° C，HR >90，呼吸频率>20和WBC <4，000/mm或>12，000/mm或>10%条带。排除诊断为感染（通过阳性培养）的患者。在241例患者中，44例有SIRS证据（18%）。调整tPA前NIHSS、年龄和人种后，SIRS仍然是出院时功能结局不良的预测因子（OR= 2.58，95% CI，1.16 - 5.73，p=0.0197）。在我们的tPA治疗的患者样本中，几乎每5名患者中就有1名发生SIRS。此外，我们发现SIRS的存在与短期功能结局差和住院时间延长有关。
Systemic Inflammatory Response (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine if differences exist in outcomes in SIRS and non-SIRS IV tPA treated patients. Consecutive patients were retrospectively reviewed for evidence of SIRS during their admission. SIRS was defined as the presence of two or more: body temperature <36° C or >38° C, HR >90, respiratory rate >20 and WBC <4,000/mm or >12,000mm or >10% bands. Patients diagnosed with infection (via positive culture) were excluded. Out of 241 patients, 44 had evidence of SIRS (18%). Adjusting for pre-tPA NIHSS, age, and race, SIRS remained a predictor of poor functional outcome at discharge (OR= 2.58, 95% CI, 1.16 – 5.73, p=0.0197). In our sample of tPA treated patients, almost 1 out of 5 patients developed SIRS. Further, we found the presence of SIRS to be associated with poor short-term functional outcomes and prolonged length of stay.