Prediction of function in protein superfamilies.
Prediction of function in protein superfamilies.
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DOI：
10.3410/b1-91
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发表时间：
2009-12-09
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影响因子：
--
通讯作者：
Copley, Shelley D
中科院分区：
文献类型：
--
作者：
Copley, Shelley D
在测序的基因组中编码的酶的功能分配是一项具有挑战性的任务。酶功能的预测可以使用来自超家族分配、结构、基因组背景、系统发育保守性和虚拟筛选的线索来确定潜在的配体。最终，自信的功能分配需要实验验证以及对酶在代谢网络背景下的生理作用的了解。
Assignment of function for enzymes encoded in sequenced genomes is a challenging task. Predictions of enzyme function can be made using clues from superfamily assignment, structure, genome context, phylogenetic conservation, and virtual screening to identify potential ligands. Ultimately, confident assignment of function requires experimental verification as well as an understanding of the physiological role of an enzyme in the context of the metabolic network.