Interactions between catecholamines, 5-hydroxytryptamine and TSH on the secretion of thyroid hormone.
Interactions between catecholamines, 5-hydroxytryptamine and TSH on the secretion of thyroid hormone.
复制标题
儿茶酚胺、5-羟色胺和 TSH 之间的相互作用对甲状腺激素分泌的影响。
DOI：
10.1210/endo-90-1-188
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发表时间：
1972
期刊：
影响因子：
4.8
通讯作者：
F. Sundler
中科院分区：
文献类型：
--
作者：
A. Melander;F. Sundler
本文研究了L-肾上腺素（E）、L-去甲肾上腺素（NE）、L-异丙肾上腺素（IPNE）、5-羟色胺（5-HT）对正常小鼠和甲状腺素阻断小鼠甲状腺激素分泌的影响。在T4阻断的小鼠中，每种胺，如TSH，诱导甲状腺中形成胶体滴，伴随着血液中131 I的增加。同时给药时，胺和TSH产生相加反应，但间隔2小时给药时，它们相互拮抗。胺和激素间隔5分钟给药时，E和NE使对TSH的反应减弱，而5-HT和IPNE与TSH呈相加反应。在正常小鼠中，E、NE和5-HT引起血中131 I水平降低。结果表明：在基础状态下，E、NE、IPNE、5-HT和TSH通过直接作用于甲状腺滤泡细胞而引起甲状腺激素的分泌。上午...
The interactions between L-epinephrine (E), L-norepinephrine (NE), L-isoproterenol (IPNE), 5-hydroxytryptamine (5-HT) and TSH on the secretion of thyroid hormone were studied in mice, in which TSH secretion was either intact (normal mice) or abolished by thyroxine (T4- blocked mice). In T4-blocked mice, each of the amines, like TSH, induced a formation of colloid droplets in the thyroid, accompanied by an increase in blood 131I. The amines and TSH produced additive responses when administered simultaneously, but they were mutually antagonistic when administered with an interval of 2 hr. With an interval of 5 min between the administration of amine and hormone, E and NE caused a diminished response to TSH, whereas 5-HT and IPNE were additive with TSH. In normal mice, E, NE and 5-HT induced a decrease in the blood 131I levels. The findings were interpreted as follows: Under basal conditions, E, NE, IPNE, 5-HT, and TSH induce secretion of thyroid hormone by direct actions on the thyroid follicle cell. The am...