Togni-II Reagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes
Togni-II Reagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes
复制标题
Togni-II 试剂介导的烯烃选择性氢三氟甲基化和氢硫醇化
DOI：
10.1002/cjoc.202100464
复制
发表时间：
2021
影响因子：
5.4
通讯作者：
Wan Qian
中科院分区：
文献类型：
--
作者：
Teng Shuang;Meng Lingkui;Xu Bingbing;Tu Guangsheng;Wu Peng;Liao Zhiwen;Tan Yulin;Guo Jian;Zeng Jing;Wan Qian
基于Togni-II试剂与硫醇的氧化还原反应，提出了一种巯基调谐的非活化烯烃选择性功能化方法。化学计量量的Togni-II试剂与芳基硫醇结合，促使烯烃发生氢三氟甲基化反应，其中芳基硫醇起到还原剂和氢源的作用；而利用烷基硫醇时，Togni-II试剂的催化量引发了硫烯和硫炔反应。所报告的应用程序的特点是操作简单和广泛的功能组容忍度。
Based on the redox reactions of Togni-II reagent and thiols, a thiol-tuned selective functionalization of unactivated olefins was disclosed.In combination with aryl thiols, stoichiometric amount of Togni-II reagent prompted a hydrotrifluoromethylation of alkenes, in which, aryl thiols played as reductant and hydrogen source;while by utilization of alkyl thiols, catalytic amount of Togni-II reagent initiated thiol-ene and thiol-yne reactions.The reported applications are characterized by their operational simplicity and wide functional group tolerance.