The H-mshi antigen is conserved among standard BALB/cBy, C57BL/6J, and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice.
The H-mshi antigen is conserved among standard BALB/cBy, C57BL/6J, and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice.
复制标题
H-mshi 抗原在标准 BALB/cBy、C57BL/6J 以及野生来源的 CAST/Ei 和 SPRET/Ei 近交系小鼠中是保守的。
DOI：
10.1007/s002510050663
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发表时间：
1999
期刊：
影响因子：
3.2
通讯作者：
King,TR
中科院分区：
文献类型：
--
作者：
Hildebrandt,AL;Cantwell,AM;Rule,MC;King,TR
在标准近交系小鼠BALB/cBy中自发产生了隐性雄性不育和组织不相容突变（mshi）。除了在纯合子雄性中产生不育外，mshi还控制着一种名为H-mshi的次要组织相容性抗原的丢失。为了确定BALB/cBy菌株（H-mshic）正常表达的H-mshi抗原是否与标准自交系C57BL/6J菌株或野生衍生的CAST/Ei和SPRET/Ei菌株表达的抗原（H-mshix）相同或不同，我们将突变抗原丢失等位基因（H-mshi -）和H-mshix杂合的动物移植到BALB/cBy小鼠的尾皮上。这些宿主对移植物的长期保留表明，由BALB/cBy、C57BL/6J、CAST/Ei和SPRET/Ei菌株编码的H-mshi抗原在组织组织学上是相同的。在这些进化上不同的菌株中，这种次要的组织相容性抗原的保存表明ath - mshii编码了一种功能重要的细胞产物。
The recessive male sterility and histoincompatibility mutation (mshi) arose spontaneously in the standard inbred mouse strain BALB/cBy. In addition to generating sterility in homozygous males,mshicontrols the loss of a minor histocompatibility antigen designated H-mshi. To determine whether the H-mshi antigen normally expressed by the BALB/cBy strain (H-mshic) is the same as or different from the antigen (H-mshix) expressed by the standard inbred C57BL/6J strain or the wild-derived CAST/Ei and SPRET/Ei strains, animals heterozygous for the mutant antigen-loss allele (H-mshi–) andH-mshixwere grafted with tail skin from BALB/cBy mice. The long-term retention of grafts by these hosts indicates that the H-mshi antigen encoded by the BALB/cBy, C57BL/6J, CAST/Ei, and SPRET/Ei strains is histogenically identical. Conservation of this minor histocompatibility antigen among these evolutionarily diverse strains suggests thatH-mshiencodes a functionally important cellular product(s).