Risk factors for detection of SARS-CoV-2 in healthcare workers during April 2020 in a UK hospital testing programme
Risk factors for detection of SARS-CoV-2 in healthcare workers during April 2020 in a UK hospital testing programme
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DOI：
10.1016/j.eclinm.2020.100513
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发表时间：
2020-09-01
影响因子：
15.1
通讯作者：
Leeds, Clare M.
中科院分区：
文献类型：
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作者：
Leeds, John S.;Raviprakash, Veena;Leeds, Clare M.
背景：卫生保健工作者（HCW）是劳动力的重要组成部分，但也可能增加感染SARS-CoV-2的风险。新出现的证据表明，特定人群的HCW风险进一步增加，特别是黑人、亚裔和少数族裔（BAME）群体。以前的报告没有检查与感染病毒的危险因素，并在英国的流行高峰之前报告。方法：在我们的设施工作人员测试开始于4月1日，所有的人都被输入到数据库。对于最初检测为阴性的患者，在前3周进行重复检测。记录人口统计学资料，包括年龄、性别、职业和种族。职业分为急症前线（例如国际电信联盟）、前线、临床支援人员及非临床人员。最后的测试状态进行了分析，使用单变量和多变量分析，以确定独立的协会与年龄，性别，职业和ethnication.Findings：991个人（平均年龄42.6岁，145名男性）进行了测试，超过4周的时间和总的440/991（43.4%）检测为SARS-CoV-2阳性。SARS-CoV-2 RNA检测率在检测第一周（59.0%）显著高于第2周（比值比0.59）、第3周（比值比0.32）和第4周（比值比0.23）（所有p
Background: Healthcare workers (HCW) are a crucial part of the workforce but are also at potentially at increased risk of infection from SARS-CoV-2. Emerging evidence has suggested specific groups of HCW are at further increased risk particularly those from Black, Asian and Minority Ethnic (BAME) groups. Previous reports have not examined risk factors associated with contracting the virus and were reported prior to the pandemic peak in the UK.Methods: Staff testing in our facility commenced on the 1st April and all individuals were entered into a database. Repeat testing was used for the first 3 weeks for those initially testing negative. Demographics including age, sex, occupation and ethnicity were recorded. Occupation was divided into acute frontline (e.g. ITU), frontline, clinical support staff and non-clinical staff. Final testing status was analysed using univariate and multivariable analysis to determine independent associations with age, sex, occupation and ethnicity.Findings: 991 individuals (mean age 42.6 years, 145 males) were tested over a 4 week period and overall 440/991 (43.4%) tested positive for SARS-CoV-2. SARS-CoV-2 RNA detection rates were significantly higher in the first week of testing (59.0%) compared to week 2 (odds ratio 0.59), week 3 (odds ratio 0.32) and week 4 (odds ratio 0.23)(all p