Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice.
Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice.
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DOI：
10.1016/j.nutres.2014.03.002
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Johnson JJ
中科院分区：
文献类型：
--
作者：
Petiwala SM;Li G;Ramaiya A;Kumar A;Gill RK;Saksena S;Johnson JJ
此前，我们已经报道了α-mangostin在小鼠体内的药代动力学特性。在这项研究中，我们使用标准化的山竹提取物在C57 BL/6小鼠中评估了α-mangostin的药代动力学特征。主要目的是确定α-倒捻子素作为提取物给药时的药代动力学特性。本实验旨在检验我们的主要假设，即提取物中的α-倒捻子素应达到理想的药代动力学特征。这一点尤其重要，因为山竹果的膳食补充剂通常被标准化为α-山竹素。小鼠口服100 mg/kg山竹果提取物，相当于36 mg/kg α-mangostin，并在24小时内分析血浆样品。通过LC-MS/MS测定α-倒捻子素的浓度。此外，我们还评估了在肝脏和胃肠道微粒体中存在I相和II相酶时的稳定性。此外，我们还发现了α-倒捻子素II相代谢的证据。需要进一步的研究来确定山竹果中含量较少的氧杂蒽酮是否可以调节α-倒捻子素的药代动力学参数。
Previously, we have reported the pharmacokinetic properties of α-mangostin in mice. For this study, we evaluated the pharmacokinetic profile of α-mangostin using a standardized mangosteen extract in C57BL/6 mice. The primary objective was to determine the pharmacokinetic properties of α-mangostin when administered as an extract. This experiment was designed to test our primary hypothesis that α-mangostin in an extract should achieve a desirable pharmacokinetic profile. This is especially relevant as dietary supplements of mangosteen fruit are regularly standardized to α-mangostin. Mice received 100 mg/kg of mangosteen fruit extract orally, equivalent to 36 mg/kg of α-mangostin, and plasma samples were analyzed over a 24 hour period. Concentrations of α-mangostin were determined by LC-MS/MS. In addition, we evaluated the stability in the presence of phase I and phase II enzymes in liver and gastrointestinal microsomes. Furthermore, we identified evidence of phase II metabolism of α-mangostin. Further research will be required to determine if less abundant xanthones present in the mangosteen may modulate the pharmacokinetic parameters of α-mangostin.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1159/000212738
发表时间：
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期刊：
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作者：
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通讯作者：
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DOI：
10.1152/ajpgi.00027.2011
发表时间：
2011-06-01
影响因子：
4.5
作者：
Saksena, Seema;Goyal, Sonia;Dudeja, Pradeep K.
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