Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia
Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia
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DOI：
10.1016/j.clinph.2010.12.056
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发表时间：
2011-08-01
影响因子：
4.7
通讯作者：
Kasai, Kiyoto
中科院分区：
文献类型：
--
作者：
Koike, Shinsuke;Takizawa, Ryu;Kasai, Kiyoto
目的：精神分裂症涉及与前额叶皮质功能相关的注意力、工作记忆和执行过程的损害，前额叶皮质功能是社会功能的重要贡献者。发病年龄是预测精神分裂症社会结局的主要因素。在临床环境中，我们需要一个客观的评估工具来评估前额叶功能和社会结果。方法：研究对象包括22名右利手精神分裂症患者和40名性别和年龄匹配的健康对照。在随机数产生(RNG)任务中，我们使用52通道近红外光谱仪(NIRS)来测量前额叶皮质氧合血红蛋白([oxy-Hb])的变化。结果：在健康对照组中，我们发现双侧背外侧(DLPFC；BA9和BA46)和腹外侧额前皮质(VLPFC；BA44、45和47)的[oxy-Hb]显著增加。在相同的近似区域，精神分裂症患者的激活程度显著低于健康对照组。在患者组中，右侧DLPFC区(BA9)较小的[oxy-Hb]升高与发病年龄较早显著相关。结论：NIRS可以检测到与执行任务相关的前额叶皮质功能障碍，这与精神分裂症患者的发病年龄较早有关。意义：多通道NIRS，一种非侵入性和用户友好的仪器，在精神病学的临床环境中可能有助于评估认知功能和社会结果。(C)2011年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objectives: Schizophrenia involves impairment in attention, working memory and executive processes associated with prefrontal cortical function, an essential contributor of social functioning. Age at onset is a major factor for predicting social outcome in schizophrenia. In clinical settings, we need an objective assessment tool for evaluating prefrontal function and social outcome.Methods: Participants included 22 right-handed patients with schizophrenia and 40 gender-and age-matched healthy controls. We used a 52-channel near-infrared spectroscopy (NIRS) instrument to measure oxygenated haemoglobin ([oxy-Hb]) changes over the prefrontal cortex during a random number generation (RNG) task.Results: In healthy controls, we found significant [oxy-Hb] increase in the bilateral dorsolateral (DLPFC; BA9 and BA46) and ventrolateral prefrontal cortex (VLPFC; BA44, 45 and 47). The patients with schizophrenia showed significantly smaller activation than the healthy controls in the same approximate regions. In the patient group, a smaller [oxy-Hb] increase in the right DLPFC region (BA9) was significantly correlated with earlier age at onset.Conclusions: NIRS can detect prefrontal cortical dysfunction associated with an executive task, which was coupled with earlier age at onset in schizophrenia.Significance: Multichannel NIRS, a non-invasive and user-friendly instrument, may be useful in evaluating cognitive function and social outcome in clinical settings in psychiatry. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.