INDUCIBLE RESISTANCE TO D-CYCLOSERINE IN BACILLUS-SUBTILIS 168
INDUCIBLE RESISTANCE TO D-CYCLOSERINE IN BACILLUS-SUBTILIS 168
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DOI：
10.1128/aac.11.5.871
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发表时间：
1977-01-01
影响因子：
4.9
通讯作者：
YOUNG, FE
中科院分区：
文献类型：
--
作者：
CLARK, VL;YOUNG, FE
亚致死浓度的d-环丝氨酸可诱导枯草芽孢杆菌168产生d-环丝氨酸抗性。对抗生素的敏感性可以通过在缺乏d-环丝氨酸的情况下生长来恢复。d-环丝氨酸的杀菌活性显然没有被抗性细胞改变，并且在抗性细胞中d-环丝氨酸仍然抑制肽聚糖的合成。d-环丝氨酸耐药性显然是由于抗生素摄取减少所致。用利福平和d-环丝氨酸同时处理细胞可防止d-环丝氨酸转运的减少，d-环丝氨酸的转运系统与B. d-环丝氨酸能够在敏感和抗性细胞中交换细胞内甘氨酸，表明d-环丝氨酸在抗性培养物中不被排除在细胞之外。
Resistance tod-cycloserine could be induced inBacillus subtilis168 by sublethal concentrations ofd-cycloserine. Sensitivity to the antibiotic could be regained by growth in the absence ofd-cycloserine. The bactericidal activity ofd-cycloserine apparently was not altered by resistant cells, and peptidoglycan synthesis was still inhibited byd-cycloserine in resistant cells. Thed-cycloserine resistance apparently resulted from a decreased uptake of the antibiotic. The decrease ind-cycloserine transport could be prevented by simultaneous treatment of the cells with rifampin andd-cycloserine.d-Cycloserine was transported by the same system as glycine inB. subtilis.d-Cycloserine was able to exchange for intracellular glycine in both sensitive and resistant cells, suggesting thatd-cycloserine is not excluded from the cell in resistant cultures.