A strategy to exploit surrogate sire technology in livestock breeding programs
A strategy to exploit surrogate sire technology in livestock breeding programs
复制标题
在牲畜育种计划中利用代孕父系技术的策略
DOI：
10.1101/199893
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Gottardo P
中科院分区：
文献类型：
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作者：
Gottardo P
背景在这项工作中，我们进行了模拟，以开发和测试的战略，利用代理公畜技术在动物育种计划。替代父系技术允许创造缺乏自身生殖细胞的雄性，但移植了来自供体雄性的精原干细胞。有了这项技术，一个单一的精英男性捐助者可以产生大量的后代，可能多达所有的生产动物在一个特定的时间periodsMethodsOne百重复的各种情况下进行。情景遵循一个共同的整体结构，但不同的策略，用于确定精英捐助者和如何使用这些捐助者在产品开发part.ResultsThe的结果，这项研究表明，使用替代公畜技术将显着增加商业公畜的遗传优点，高达6.5至9.2年的遗传增益相比，传统的育种计划。模拟表明，涉及三个阶段（最初的基因组测试，随后两个后续的后代测试）的策略是最有效的所有strategies tested.ConclusionsThe使用一个或少数精英捐助者产生的生产动物将是非常不同的，目前的做法。虽然这些结果证明了替代公畜技术的巨大潜力，但也存在相当大的风险，但也存在其他机会。实际实施的替代父系技术将需要考虑到这些。
BackgroundIn this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in animal breeding programs. Surrogate sire technology allows the creation of males that lack their own germline cells, but have transplanted spermatogonial stem cells from donor males. With this technology, a single elite male donor could give rise to huge numbers of progeny, potentially as much as all the production animals in a particular time period.MethodsOne hundred replicates of various scenarios were performed. Scenarios followed a common overall structure but differed in the strategy used to identify elite donors and how these donors were used in the product development part.ResultsThe results of this study showed that using surrogate sire technology would significantly increase the genetic merit of commercial sires, by as much as 6.5 to 9.2 years’ worth of genetic gain compared to a conventional breeding program. The simulations suggested that a strategy involving three stages (an initial genomic test followed by two subsequent progeny tests) was the most effective of all the strategies tested.ConclusionsThe use of one or a handful of elite donors to generate the production animals would be very different to current practice. While the results demonstrate the great potential of surrogate sire technology there are considerable risks but also other opportunities. Practical implementation of surrogate sire technology would need to account for these.