Impact of Antiretroviral Therapy on Cancer Treatment Outcomes among People Living with HIV in Low- and Middle-Income Countries: a Systematic Review.
Impact of Antiretroviral Therapy on Cancer Treatment Outcomes among People Living with HIV in Low- and Middle-Income Countries: a Systematic Review.
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DOI：
10.1007/s11904-021-00542-5
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发表时间：
2021-04
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在低收入和中等收入国家 (LMIC) 的艾滋病毒感染者 (PLWH) 中，抗逆转录病毒治疗 (ART) 与癌症治疗结果之间的关系很复杂，而且对于许多癌症而言，人们知之甚少。我们的目的是总结中低收入国家关于 ART 对癌症治疗相关结果的益处的现有证据。我们纳入了 12 项观察性研究，报告了中低收入国家 HIV 阳性患者的 ART 状态与癌症治疗结果之间的关联。大多数已证实的 ART 与改善癌症治疗结果有关。所研究的癌症、结果测量、ART状态的分类以及HIV相关免疫功能的报告的异质性使得研究之间的正式比较站不住脚。经过评估，ART 通常对中低收入国家的 HIV 感染者的癌症结局产生积极影响。然而，关于 ART 对大多数癌症类型治疗结果的影响，文献中仍存在很大差距。未来的研究应侧重于 ART 和 PLWH 癌症治疗的最佳时机和整合，以及适用于资源有限环境的策略。
The relationship between antiretroviral therapy (ART) and cancer treatment outcomes among people living with HIV (PLWH) in low- and middle-income countries (LMICs) is complex and poorly understood for many cancers. We aimed to summarize existing evidence from LMICs regarding the benefit of ART on cancer treatment–related outcomes. We included twelve observational studies that reported associations between ART status and cancer treatment outcomes among HIV-positive patients in LMICs. Most confirmed ART was associated with improved cancer treatment outcomes. Heterogeneity in cancers under study, outcome measurement, categorization of ART status, and reporting of HIV-related immune function made formal comparison between studies untenable. Where evaluated, ART generally has a positive effect on cancer outcomes in people with HIV in LMICs. However, there remains a substantial gap in the literature regarding the impact of ART on treatment outcomes for most cancer types. Future research should focus on the optimal timing and integration of ART and cancer treatment for PLWH with strategies applicable to constrained-resource settings.
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影响因子：
2.7
作者：
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通讯作者：
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2.1
作者：
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DOI：
10.1016/j.ijrobp.2018.01.067
发表时间：
2018-05-01
影响因子：
7
作者：
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通讯作者：
Lin, Lilie L.