Effects of dermal sub-chronic exposure of pubescent male rats to permethrin (PRMT) on the histological structures of genital tract, testosterone and lipoperoxidation
Effects of dermal sub-chronic exposure of pubescent male rats to permethrin (PRMT) on the histological structures of genital tract, testosterone and lipoperoxidation
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DOI：
10.1016/j.etp.2010.02.016
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发表时间：
2011-05-01
影响因子：
--
通讯作者：
Hassen, Ben Cheikh
中科院分区：
文献类型：
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作者：
Issam, Chargui;Zohra, Haouas;Hassen, Ben Cheikh
拟除虫菊酯类杀虫剂对人类健康的短期影响已得到较好的确认，但长期风险，特别是影响生殖功能的风险，仍然难以估计。本研究在雄性大鼠中进行，旨在探讨氯菊酯（PRMT）毒性的一些影响。本研究旨在探讨不同剂量PRMT皮下处理对青春期雄性大鼠睾丸和附睾组织病理学、睾酮和氧化应激的影响。每组6只动物分别以0.013、0.13或1.3 mg/kg体重/天的70%乙醇为皮肤日剂量给药30、45和60天。宏观研究显示PRMT对睾丸、附睾和体重有影响。拟除虫菊酯可引起精子发生异常引起的睾丸紊乱，并可引起附睾微结构强烈变形引起的附睾功能障碍。血浆睾酮浓度的测量证实了激素的紊乱。本调查的结果提到了一个显著的增加（第394页）
Short-term effects of pyrethroids on human health are better and well identified, whereas long-term risk's estimation remains difficult, especially those affecting the reproductive function. The present study, carried out in male rats, is a contribution to explore some effects underlying permethrin (PRMT) toxicity. The aim of the present work was to investigate the effect of different subcutaneous treatments with PRMT low doses on testes and epididymides histopathology, testosterone and oxidative stress in pubescent male rats. Groups of six animals were treated with a dermal daily dose of 0.013, 0.13, or 1.3 mg/kg b.w/day of PRMT in 70% ethanol for 30, 45, and 60 days, respectively.Macroscopic studies showed an influence of PRMT on the testes, the epididymides and body weight. The pyrethroid induces a testis disturbance traduced by a deregulation of spermatogenesis and an epididymis dysfunction by the appearance of strong deformations into the microstructure of the epididymides. A hormonal disruption was evidenced by the measurement of the plasma testosterone concentrations. The findings of the present investigation mentioned a significant increase (p