Effects of attentional bias modification therapy on the cue reactivity and cognitive control networks in participants with cocaine use disorders.
Effects of attentional bias modification therapy on the cue reactivity and cognitive control networks in participants with cocaine use disorders.
复制标题
注意偏差修正疗法对可卡因使用障碍参与者的提示反应性和认知控制网络的影响。
DOI：
10.1080/00952990.2019.1671437
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Bryan,AngelaD
中科院分区：
文献类型：
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作者：
Mayer,AndrewR;Dodd,AndrewB;Wilcox,ClaireE;Klimaj,StefanD;Claus,EricD;Bryan,AngelaD
背景虽然注意力偏向修正疗法（ABMT）改变了一些物质使用者的药物相关行为，但在可卡因使用障碍（CUD）个体中结果却参差不齐。 目的当前的研究探讨了在独立测量线索反应性（即可卡因与食物线索）和认知控制（即不一致与一致试验）期间，ABMT是否影响大脑功能，以及大脑活动是否与基线或干预后可卡因相关。方法 37 名参与者（62% 为男性）被随机分配接受 ABMT 或对照治疗。在基线和干预后立即进行临床和神经影像评估，并在干预后 2 周和 3 个月进行额外的临床测试。通过自我报告评估可卡因的使用情况。结果与一致刺激相比，观察到不一致刺激的反应时间更慢，功能激活增加（前额叶皮层、后顶叶皮层），并且相对于食物视频（腹侧纹状体、背外侧前额叶皮层和眶额皮层），可卡因的功能激活增加。在接触可卡因视频期间，默认模式网络 (DMN) 并未停用。可卡因相对于食物线索的激活程度与基线可卡因使用（仅岛叶）和治疗后使用减少（岛叶和前DMN）的相关性高于临床变量。认知控制网络活动与基线或治疗后使用可卡因无关。 ABMT 疗法对任一任务期间的可卡因使用或功能激活均没有差异。 结论 目前的结果表明线索反应网络激活与可卡因使用之间存在关系，但质疑 ABMT 在线索反应或认知控制任务期间改变大脑功能的功效。
BackgroundWhile attentional bias modification therapy (ABMT) alters drug-related behaviors in some substance users, results have been mixed in individuals with cocaine use disorders (CUD).ObjectivesThe current study examined whether ABMT affected brain functioning during independent measures of cue reactivity (i.e., cocaine versus food cues) and cognitive control (i.e., incongruent versus congruent trials), and whether brain activity was associated with baseline or post-intervention cocaine use.Methods37 participants (62% male) were randomly assigned to ABMT or control therapy. Clinical and neuroimaging assessments occurred at baseline and immediately post-intervention, with additional clinical testing at 2 weeks and 3 months following intervention. Cocaine use was assessed through self-report.ResultsSlower reaction times and increased functional activation (prefrontal cortex, posterior parietal cortex) were observed for incongruent versus congruent stimuli and increased functional activation for cocaine relative to food videos (ventral striatum, dorsolateral prefrontal cortex and orbitofrontal cortex). The default-mode network (DMN) was not deactivated during exposure to cocaine videos. The degree of activation during cocaine relative to food cues was associated with baseline cocaine use (insula only) and reduction in use following treatment (insula and anterior DMN) above and beyond clinical variables. Cognitive control network activity was not associated with cocaine use at baseline or following treatment. ABMT therapy did not differentially affect cocaine use or functional activation during either task.ConclusionCurrent results suggest a relationship between cue reactivity network activation and cocaine use, but question the efficacy of ABMT in changing brain function during cue reactivity or cognitive control tasks.