Supplementation with β-hydroxy-β-methylbutyrate (HMB) and α-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man
Supplementation with β-hydroxy-β-methylbutyrate (HMB) and α-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man
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DOI：
10.1123/ijsnem.15.4.413
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发表时间：
2005-08-01
影响因子：
2.5
通讯作者：
Howatson, G
中科院分区：
文献类型：
--
作者：
van Someren, KA;Edwards, AJ;Howatson, G
本研究探讨了补充 β-羟基-β-甲基丁酸 (HMB) 和 α-酮异己酸 (KIC) 对单次偏向离心阻力运动后运动引起的肌肉损伤体征和症状的影响。六名未接受过阻力训练的男性受试者在两个不同的场合执行了一项旨在诱发肌肉损伤的运动方案，以平衡交叉设计在主导臂或非主导臂上进行。在平衡交叉设计中运动前，受试者被分配至 HMB/KIC（每天 3 g HMB 和 0.3 g α-酮异己酸）或安慰剂治疗组 14 天。在运动前、运动后 1 小时、24 小时、48 小时和 72 小时测定一次最大重复次数 (1RM)、血浆肌酸激酶活性 (CK)、迟发性肌肉酸痛 (DOMS)、肢体周长和运动范围 (ROM)。 DOMS 以及 1RM、肢体周长和 ROM 的百分比变化在 72 小时内均发生变化 (P < 0.05)。 HMB/KIC 补充剂减弱了 CK 反应、1RM 的减少百分比和肢体周长的增加百分比（P < 0.05）。此外，在 HMB/KIC 治疗中，运动后 24 小时 DOMS 降低 (1 < 0.05)。总之，对于未接受过阻力训练的男性，在进行单轮离心偏向阻力运动后，补充 14 天的 HMB 和 KIC 可减少运动引起的肌肉损伤的体征和症状。
This study examined the effects of beta-hydroxy- beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) supplementation on signs and symptoms of exercise-induced muscle damage following a single bout of eccentrically biased resistance exercise. Six non-resistance trained male subjects performed an exercise protocol designed to induce muscle damage on two separate occasions, performed on the dominant or non-dominant arm in a counter-balanced crossover design. Subjects were assigned to an HMB/KIC (3 g HMB and 0.3 g alpha-ketoisocaproic acid, daily) or placebo treatment for 14 d prior to exercise in the counter-balanced crossover design. One repetition maximum (1RM), plasma creatine kinase activity (CK), delayed onset muscle soreness (DOMS), limb girth, and range of motion (ROM) were determined pre-exercise, at 1h, 24 h, 48 h, and 72 h post-exercise. DOMS and the percentage changes in 1RM, limb girth, and ROM all changed over the 72 h period (P < 0.05). HMB/KIC supplementation attenuated the CK response, the percentage decrement in 1RM, and the percentage increase in limb girth (P < 0.05). In addition, DOMS was reduced at 24 h post-exercise (1 < 0.05) in the HMB/KIC treatment. In conclusion, 14 d of HMB and KIC supplementation reduced signs and symptoms of exercise-induced muscle damage in non-resistance trained males following a single bout of eccentrically biased resistance exercise.