Altered gut microbiota and microbial biomarkers associated with chronic kidney disease
Altered gut microbiota and microbial biomarkers associated with chronic kidney disease
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与慢性肾病相关的肠道微生物群和微生物生物标志物的改变
DOI：
10.1002/mbo3.678
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发表时间：
2019-04-01
期刊：
影响因子：
3.4
通讯作者：
Wang, Yunshan
中科院分区：
文献类型：
--
作者：
Lun, Hengzhong;Yang, Weihua;Wang, Yunshan
本研究旨在确定慢性肾脏病（CKD）患者和健康对照（HC）之间肠道微生物群的差异，并寻找与CKD相关的更好的微生物生物标志物。使用16S rRNA基因测序方法来研究CKD和HC组之间肠道微生物群的差异。该研究发现，在属水平上，CKD组中有12种类型过度表达，HC组中有19种。此外，毛螺菌属和瘤胃球菌属在区分HC和CKD种群方面表现最好。此外，这项新的研究发现，Holdemanella，Megamonas，Prevotella 2，Dielma和Scardovia属与CKD和血液透析的进展相关。总之，与健康人群相比，CKD人群的肠道菌群组成不同，毛螺菌和R. gnavus是较好的微生物生物标志物。此外，包括Holdemanella、Megamonas、Prevotella 2、Dielma和Scardovia在内的五种细菌类型可作为CKD和血液透析进展的指标。然而，应该进行大规模的前瞻性研究，以确定这些生物标志物的可靠性。
The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease (CKD) and healthy controls (HC) and search for better microbial biomarkers associated with CKD. The 16S rRNA gene sequencing approach was used to investigate the differences in gut microbiota between the CKD and HC groups. The study found that 12 phylotypes were overrepresented in the CKD group and 19 in the HC group at the genus level. Furthermore, genera Lachnospira and Ruminococcus_gnavus performed the best in differentiating between HC and CKD populations. In addition, this novel study found that the genera Holdemanella, Megamonas, Prevotella 2, Dielma, and Scardovia were associated with the progression of CKD and hemodialysis. In conclusion, the composition of gut microbiota was different in CKD populations compared with healthy populations, and Lachnospira and R._gnavus were better microbial biomarkers. In addition, five phylotypes, including Holdemanella, Megamonas, Prevotella2, Dielma, and Scardovia, served as an indicator of the progression of CKD and hemodialysis. However, large‐scale prospective studies should be performed to identify the reliability of the set of these phylotypes as biomarkers.