Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder
Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder
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DOI：
10.1093/brain/awm277
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发表时间：
2008-01-01
期刊：
影响因子：
14.5
通讯作者：
Kwon, Jun Soo
中科院分区：
文献类型：
--
作者：
Gu, Bon-Mi;Park, Ji-Young;Kwon, Jun Soo
认知灵活性的缺陷被认为是强迫症（OCD）的认知特征。然而，迄今为止还没有研究使用认知激活范式来指定这种缺陷在强迫症中的神经相关性。本研究的目的是澄清异常的大脑活动与认知能力的强迫症，使用任务转换范式。采用两种任务集的任务转换范式，对21例强迫症患者和21名年龄、智商、性别相匹配的健康人进行事件相关功能磁共振成像实验。强迫症患者在任务转换实验中的错误率显著高于正常人（P < 0.05）。在任务转换过程中，健康对照组的各个区域（包括背侧额叶-纹状体区域）都有明显的激活，而强迫症患者的这些区域没有激活。在强迫症患者和健康对照组之间的背侧额叶-纹状体区和腹内侧前额叶和右眶额皮质也观察到显着差异。相关分析表明，两组眶额皮层的激活与作业成绩有关，强迫症组的眶额皮层激活与前扣带回的激活也有关。这些发现重复了以前的研究，认知能力强迫症，并提供神经相关的任务转换缺陷强迫症。结果表明，强迫症患者的任务转换能力受损可能与背侧和腹侧额叶-纹状体回路之间的脑激活不平衡有关。
A deficit in cognitive flexibility is acknowledged as a cognitive trait for obsessive-compulsive disorder (OCD). However, no investigations to date have used a cognitive activation paradigm to specify the neural correlates of this deficit in OCD. The objective of this study was to clarify how abnormal brain activities relate to cognitive inflexibility in OCD, using a task-switching paradigm. A task-switching paradigm which has two kinds of task-set was applied to 21 patients with OCD and 21 healthy subjects of matching age, IQ and sex, during an event-related functional magnetic resonance imaging experiment. Compared with the healthy subjects, patients with OCD exhibited a significantly higher error rate in task-switch trials (P < 0.05). Healthy controls showed significant activation in various areas, including dorsal frontal-striatal regions, during task-switching, whereas patients with OCD showed no activation in these areas. Significant differences were also observed in the dorsal frontal-striatal regions and ventromedial prefrontal and right orbitofrontal cortexes between patients with OCD and healthy controls. Correlation analysis indicated that the activations of orbitofrontal cortex were related with the performance in both groups and also with the activation of anterior cingulate cortex in the OCD group. These findings replicate previous studies of cognitive inflexibility in OCD and provide neural correlates related to a task-switching deficit in OCD. The results suggest that impaired task-switching ability in OCD patients might be associated with an imbalance in brain activation between dorsal and ventral frontal-striatal circuits.