Predicting the molecular interactions of CRIP1a-cannabinoid 1 receptor with integrated molecular modeling approaches
Predicting the molecular interactions of CRIP1a-cannabinoid 1 receptor with integrated molecular modeling approaches
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DOI：
10.1016/j.bmcl.2013.12.119
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发表时间：
2014-02-15
影响因子：
2.7
通讯作者：
Zhang, Yan
中科院分区：
文献类型：
--
作者：
Ahmed, Mostafa H.;Kellogg, Glen E.;Zhang, Yan
大麻素受体是 G 蛋白偶联受体家族，参与多种生理过程和疾病。大麻素受体独特的关键调节因子之一是大麻素受体相互作用蛋白（CRIP）。其中CRIP1a被发现可以降低大麻素1型受体（CB1R）的组成活性。本研究的目的是通过使用不同的计算技术来了解 CRIP1a 和 CB1R 之间的相互作用。生成的模型证明了 CRIP1a 和 CB1R 之间的几个关键的假定相互作用，包括 Lys130 在 CRIP1a 中的关键参与。由爱思唯尔有限公司出版
Cannabinoid receptors are a family of G-protein coupled receptors that are involved in a wide variety of physiological processes and diseases. One of the key regulators that are unique to cannabinoid receptors is the cannabinoid receptor interacting proteins (CRIPs). Among them CRIP1a was found to decrease the constitutive activity of the cannabinoid type-1 receptor (CB1R). The aim of this study is to gain an understanding of the interaction between CRIP1a and CB1R through using different computational techniques. The generated model demonstrated several key putative interactions between CRIP1a and CB1R, including the critical involvement of Lys130 in CRIP1a. Published by Elsevier Ltd.