SLOW MORTALITY-RATE ACCELERATIONS DURING AGING IN SOME ANIMALS APPROXIMATE THAT OF HUMANS
SLOW MORTALITY-RATE ACCELERATIONS DURING AGING IN SOME ANIMALS APPROXIMATE THAT OF HUMANS
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DOI：
10.1126/science.2392680
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发表时间：
1990-08-24
期刊：
影响因子：
56.9
通讯作者：
WITTEN, M
中科院分区：
文献类型：
--
作者：
FINCH, CE;PIKE, MC;WITTEN, M
衰老速度的一般衡量标准是死亡率的加速，这里用死亡率加倍所需的时间（MRD）来表示。恒河猴的MRD与人类接近，约为8年；他们寿命较短的主要原因是各个年龄段的死亡率较高。相比之下，一些寿命较短的群体（啮齿动物和鸡形鸟类）的 MRD 较短，衰老速度较快。根据Gompertz死亡率模型，可以根据最大寿命（tmax）和总体人口死亡率来估计MRD。这样的计算表明，某些鸟类的 MRD 与人类一样长。这些结果表明，总体死亡率高或体型小并不排除衰老速度缓慢。
A general measure of the rate of senescence is the acceleration of mortality rate, represented here by the time required for the mortality rate to double (MRD). Rhesus monkeys have an MRD close to that of humans, about 8 years; their shorter life-span results mainly from higher mortality at all ages. In contrast, some groups with short life-spans (rodents and galliform birds) have shorter MRDs and faster senescence. On the basis of the Gompertz mortality rate model, one may estimate the MRD from the maximum life-span (tmax) and the overall population mortality rate. Such calculations show that certain birds have MRDs that are as long as that of humans. These results show that high overall mortality rates or small body sizes do not preclude slow rates of senescence.