Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions
Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions
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DOI：
10.1021/ol062808f
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发表时间：
2007-02-01
期刊：
影响因子：
5.2
通讯作者：
Wolfe, John P.
中科院分区：
文献类型：
--
作者：
Bertrand, Myra Beaudoin;Leathen, Matthew L.;Wolfe, John P.
在弱碱Cs_2CO_3存在下，以二氧六环为溶剂，钯催化N-保护的γ-氨基烯烃与芳基溴和三氟甲磺酸酯的碳胺化反应在新的温和条件下完成。这些反应容许各种各样的官能团，包括可烯醇化的酮、硝基、甲酯和乙酸酯，其与先前描述的条件不相容。
The palladium-catalyzed carboamination of N-protected gamma-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs2CO3 in dioxane solvent. These reactions tolerate a wide variety of functional groups, including enolizable ketones, nitro groups, methyl esters, and acetates, which are not compatible with previously described conditions.