Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice
Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice
复制标题
X连锁凋亡蛋白抑制剂的过度表达可减缓C57BL/6J小鼠的老年性耳聋
DOI：
10.1016/j.neurobiolaging.2008.07.016
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
殷善开
中科院分区：
文献类型：
--
作者：
殷善开
Apoptosis of cochlear cells plays a significant role in age-related hearing loss or presbycusis. In this study, we evaluated whether over-expression of the anti-apoptotic protein known as X-linked Inhibitor of Apoptosis Protein (XIAP) slows the development of presbycusis. We compared the age-related hearing loss between transgenic (TG) mice that over-express human XIAP tagged with 6-Myc (Myc-XIAP) on a pure C57BL/6J genetic background with wild-type (WT) littermates by measuring auditory brainstem responses. The result showed that TG mice developed hearing loss considerably more slowly than WT littermates, primarily within the high-frequency range. The average total hair cell loss was significantly less in TG mice than WT littermates. Although levels of Myc-XIAP in the ear remained constant at 2 and 14 months, there was a marked increase in the amount of endogenous XIAP from 2 to 14 months in the cochlea, but not in the brain, in both genotypes. These results suggest that XIAP over-expression reduces age-related hearing loss and hair cell death in the cochlea.
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影响因子：
2.8
作者：
E. Keithley;A. Ryan;M. Feldman
通讯作者：
E. Keithley;A. Ryan;M. Feldman
影响因子：
2.8
作者：
S. Spicer;B. A. Schulte
通讯作者：
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影响因子：
3.5
作者：
J. Y. Wu;L. Muldoon;E. Neuwelt
通讯作者：
J. Y. Wu;L. Muldoon;E. Neuwelt
DOI：
--
发表时间：
2011
期刊：
--
影响因子：
--
作者：
友森麻衣子;石原具和;塩澤深雪;藤田直人;浜本和子;西美和
通讯作者：
友森麻衣子;石原具和;塩澤深雪;藤田直人;浜本和子;西美和
影响因子：
4.7
作者：
M. Simons;S. Beinroth;M. Gleichmann;P. Liston;R. Korneluk;A. MacKenzie;M. Bähr;T. Klockgether;G. Robertson;M. Weller;J. Schulz
通讯作者：
M. Simons;S. Beinroth;M. Gleichmann;P. Liston;R. Korneluk;A. MacKenzie;M. Bähr;T. Klockgether;G. Robertson;M. Weller;J. Schulz