An international case-control study of interleukin-4Rα, interieukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk
An international case-control study of interleukin-4Rα, interieukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk
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DOI：
10.1158/1055-9965.epi-07-0480
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发表时间：
2007-11-01
影响因子：
3.8
通讯作者：
Feychting, Maria
中科院分区：
文献类型：
--
作者：
Schwartzbaum, Judith A.;Ahlbom, Anders;Feychting, Maria
先前的研究发现过敏与神经胶质瘤的风险呈负相关。在早期的一篇出版物中，Schwartzbaum等人使用瑞典病例对照研究的数据报告了胶质母细胞瘤风险与两种基因[白细胞介素（IL）-4R α、IL-13]上的四种单核苷酸多态性（SNP）之间的负相关关系。与过敏相关。此外，最近的研究表明，IL-4和IL-13诱导环氧合酶-2（考克斯-2）来解决脑炎症。看看之前瑞典的结果（110例，430例对照）将被复制，我们估计胶质母细胞瘤和两个IL-4 R α之间的关联（rs 1805015、rs 1801275）和两个IL-13（rs 20541，rs 1800925）SNP及其单倍型和一个考克斯-2 SNP（-765 GC，使用额外的英语、丹麦语和芬兰语数据（217例，1，171对照）。在一般人群对照中，我们评估了这些单倍型、考克斯-2 SNP和自我报告的过敏之间的关联。我们的数据并不支持我们最初的观察结果，即单个IL-4 R α、IL-13或考克斯-2单核苷酸多态性与胶质母细胞瘤风险相关。然而，T-G IL-4 Ra单倍型与胶质母细胞瘤风险相关（比值比，2.26; 95%置信区间，1.13-4.52），并且提示该单倍型与对照组中的花粉热患病率呈负相关（比值比，0.38; 95%置信区间，0.14-1.03）。缺乏对四种IL-4 R α和IL-13 SNP与胶质母细胞瘤之间的联系的支持可能反映了缺乏相关性，或者可能是由于与我们检查的那些和胶质母细胞瘤相关的单倍型的不受控制的混淆。尽管如此，T-G IL-4 R α单倍型和胶质母细胞瘤风险之间的关联可能表明免疫因素在胶质母细胞瘤发展中的作用。
Previous studies found that allergies are inversely related to risk of glioma. In an earlier publication, using data from a Swedish case-control study, Schwartzbaum et al. report an inverse relation between risk of glioblastoma and four single nucleotide polymorphisms (SNP) on two genes [interleukin (IL)-4R alpha, IL-13] that are associated with allergies. In addition, recent studies suggest that IL-4 and IL-13 induce cyclooxygenase-2 (COX-2) to resolve brain inflammation. To see whether previous Swedish results (110 cases, 430 controls) would be replicated, we estimated the association between glioblastoma and two IL-4R alpha (rs1805015, rs1801275) and two IL-13 (rs20541, rs1800925) SNPs and their haplotypes and one COX-2 SNP (-765GC using additional English, Danish, and Finnish data (217 cases, 1,171 controls). Among general population controls, we evaluated associations between these haplotypes, the COX-2 SNP, and self-reported allergies. Our data did not support our original observations relating individual IL-4R alpha, IL-13, or COX-2 SNPs to glioblastoma risk. However, the T-G IL-4Ra haplotype was associated with glioblastoma risk (odds ratio, 2.26; 95% confidence interval, 1.13-4.52) and there was a suggestion of an inverse relation between this haplotype and hayfever prevalence among controls (odds ratio, 0.38; 95% confidence interval, 0.14-1.03). The lack of support for a link between four IL-4R alpha and IL-13 SNPs and glioblastoma may reflect the absence of associations or may result from uncontrolled confounding by haplotypes related both to those that we examined and glioblastoma. Nonetheless, the association between the T-G IL-4R alpha haplotype and glioblastoma risk may indicate a role of immune factors in glioblastoma development.